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Anxa6 annexin A6 [ Mus musculus (house mouse) ]

Gene ID: 11749, updated on 23-Jun-2021

Summary

Official Symbol
Anxa6provided by MGI
Official Full Name
annexin A6provided by MGI
Primary source
MGI:MGI:88255
See related
Ensembl:ENSMUSG00000018340
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A; An; Cab; Cam; Anx6; Cabm; Camb; AnxVI; AW107198
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 129.0), limb E14.5 (RPKM 86.9) and 27 other tissues See more
Orthologs
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Genomic context

See Anxa6 in Genome Data Viewer
Location:
11 B1.3; 11 32.13 cM
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54869779..54924297, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54978953..55033471, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (54792464..54846973, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 3 Neighboring gene TNFAIP3 interacting protein 1 Neighboring gene 40S ribosomal protein S11-like Neighboring gene predicted gene, 19911 Neighboring gene coiled-coil domain containing 69 Neighboring gene GM2 ganglioside activator protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cholesterol binding ISO
Inferred from Sequence Orthology
more info
 
enables chondroitin sulfate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligand-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ligand-gated ion channel activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in growth plate cartilage chondrocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in mitochondrial calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of sequestering of calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in plasma membrane repair IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intercalated disc ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
annexin A6
Names
67 kDa calelectrin
CPB-II
annexin VI, p68
annexin-6
calphobindin-II
chromobindin-20
lipocortin VI
p68
p70

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110211.2NP_001103681.1  annexin A6 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AK146509, AK147066, AK160754, BB033332, BY316619
    Consensus CDS
    CCDS48799.1
    UniProtKB/Swiss-Prot
    P14824
    UniProtKB/TrEMBL
    F8WIT2, Q3TUI1, Q3UI56
    Related
    ENSMUSP00000099788.3, ENSMUST00000102727.3
    Conserved Domains (2) summary
    smart00335
    Location:538587
    ANX; Annexin repeats
    pfam00191
    Location:439504
    Annexin; Annexin
  2. NM_013472.5NP_038500.2  annexin A6 isoform a

    See identical proteins and their annotated locations for NP_038500.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK146509, AK147066, BB033332, BY316619
    Consensus CDS
    CCDS24705.1
    UniProtKB/Swiss-Prot
    P14824
    UniProtKB/TrEMBL
    Q3UI56
    Related
    ENSMUSP00000104511.4, ENSMUST00000108883.10
    Conserved Domains (1) summary
    pfam00191
    Location:439504
    Annexin; Annexin

RNA

  1. NR_138556.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL593846

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    54869779..54924297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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