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Asb10 ankyrin repeat and SOCS box-containing 10 [ Mus musculus (house mouse) ]

Gene ID: 117590, updated on 5-Mar-2024

Summary

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Official Symbol
Asb10provided by MGI
Official Full Name
ankyrin repeat and SOCS box-containing 10provided by MGI
Primary source
MGI:MGI:2152836
See related
Ensembl:ENSMUSG00000038204 AllianceGenome:MGI:2152836
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asb-10
Summary
Predicted to be involved in intracellular signal transduction. Predicted to be located in cytoplasm and nucleus. Is expressed in limb and limb mesenchyme. Orthologous to human ASB10 (ankyrin repeat and SOCS box containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in heart adult (RPKM 42.5) and mammary gland adult (RPKM 4.3) See more
Orthologs
human all
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Genomic context

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Location:
5 A3; 5 11.93 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24737695..24745976, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24532697..24540978, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene VISTA enhancer mm1191 Neighboring gene gastrulation brain homeobox 1 Neighboring gene STARR-positive B cell enhancer mm9_chr5:24035915-24036216 Neighboring gene IQ motif containing with AAA domain 1 like Neighboring gene STARR-positive B cell enhancer ABC_E6314 Neighboring gene ATP-binding cassette, sub-family F member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article
  2. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
  4. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310476.1 → NP_001297405.1  ankyrin repeat and SOCS box protein 10 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC116136, AK028538, AK052929
    Consensus CDS
    CCDS80229.1
    UniProtKB/TrEMBL
    D3YU18
    Related
    ENSMUSP00000112743.2, ENSMUST00000117900.8
    Conserved Domains (5) summary
    cd00204
    Location:103 → 220
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03587
    Location:406 → 445
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    pfam12796
    Location:137 → 230
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:102 → 153
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:133 → 163
    ANK; ANK repeat [structural motif]

  2. NM_080444.5 → NP_536692.1  ankyrin repeat and SOCS box protein 10 isoform 1

    See identical proteins and their annotated locations for NP_536692.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC116136, AK028538, AK052929
    Consensus CDS
    CCDS19124.1
    UniProtKB/Swiss-Prot
    B2RUP6, Q91ZT7
    UniProtKB/TrEMBL
    D3Z651
    Related
    ENSMUSP00000041539.7, ENSMUST00000048302.13
    Conserved Domains (5) summary
    cd00204
    Location:118 → 235
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03587
    Location:421 → 460
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
    pfam12796
    Location:152 → 245
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:117 → 168
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:148 → 178
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    24737695..24745976 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91ZT7.1 GenPept UniProtKB/Swiss-Prot:Q91ZT7

Gene LinkOut

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