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Ar androgen receptor [ Mus musculus (house mouse) ]

Gene ID: 11835, updated on 27-Jul-2021

Summary

Official Symbol
Arprovided by MGI
Official Full Name
androgen receptorprovided by MGI
Primary source
MGI:MGI:88064
See related
Ensembl:ENSMUSG00000046532
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tfm; AW320017
Summary
This gene encodes a nuclear hormone receptor containing zinc finger and DNA-binding domains. The encoded protein is a key regulator of signalling by androgens, a class of steroid hormones involved in male reproductive development. The protein responds to hormone signalling by translocating to the nucleus, forming dimers, and binding to androgen response elements (AREs) in the promoters of target genes, which are subsequently transcriptionally activated. Activity of this protein is negatively regulated by nuclear receptor subfamily 0 group B member 1 (Nr0b1, also known as Dax1). Mutations in this gene result in feminized genitals and infertility in male animals. Loss of function in female animals also causes problems in reproductive development and function. [provided by RefSeq, May 2015]
Expression
Biased expression in adrenal adult (RPKM 4.7), genital fat pad adult (RPKM 4.4) and 12 other tissues See more
Orthologs
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Genomic context

Location:
X C3; X 42.82 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (97192363..97366824)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (98148757..98323218)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (95345089..95512486)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L10 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein M pseudogene Neighboring gene dCMP deaminase pseudogene Neighboring gene oligophrenin 1 Neighboring gene predicted gene, 26000

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
enables POU domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables androgen binding ISO
Inferred from Sequence Orthology
more info
 
enables androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nuclear receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nuclear receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables ribonucleotide binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables steroid binding IEA
Inferred from Electronic Annotation
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Leydig cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within activation of prostate induction by androgen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to estrogen stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to steroid hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to testosterone stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to testosterone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in copulation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell differentiation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial cell morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within fertilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular steroid hormone receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within lateral sprouting involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male courtship behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within male genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male gonad development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within male gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male sex differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within male somatic sex determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland alveolus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within morphogenesis of an epithelial fold IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of integrin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in prostate gland development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of insulin-like growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of integrin biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of intracellular estrogen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of penile erection ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within prostate gland epithelium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within prostate gland growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of developmental growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of prostatic bud formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of systemic arterial blood pressure IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in reproductive behavior ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within reproductive structure development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within reproductive system development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within seminiferous tubule development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within seminiferous tubule development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within single fertilization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in skeletal muscle hypertrophy ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within tertiary branching involved in mammary gland duct morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
androgen receptor
Names
dihydrotestosterone receptor
nuclear receptor subfamily 3 group C member 4
testicular feminization

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013476.4NP_038504.1  androgen receptor

    See identical proteins and their annotated locations for NP_038504.1

    Status: REVIEWED

    Source sequence(s)
    AK133647, AL683800, AL844866, M37890
    Consensus CDS
    CCDS30294.1
    UniProtKB/Swiss-Prot
    P19091
    Related
    ENSMUSP00000052648.8, ENSMUST00000052837.9
    Conserved Domains (3) summary
    cd07073
    Location:652897
    NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
    cd07173
    Location:534615
    NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
    pfam02166
    Location:6440
    Androgen_recep; Androgen receptor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    97192363..97366824
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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