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Arf2 ADP-ribosylation factor 2 [ Mus musculus (house mouse) ]

Gene ID: 11841, updated on 11-Apr-2024

Summary

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Official Symbol
Arf2provided by MGI
Official Full Name
ADP-ribosylation factor 2provided by MGI
Primary source
MGI:MGI:99595
See related
Ensembl:ENSMUSG00000062421 AllianceGenome:MGI:99595
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable GTP binding activity and protein domain specific binding activity. Predicted to be involved in intracellular protein transport and vesicle-mediated transport. Predicted to act upstream of or within protein transport. Located in Golgi apparatus. Is expressed in several structures, including central nervous system; cranium; endocrine gland; nasal septum; and reproductive system. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to several human genes including ARF1 (ADP ribosylation factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 36.6), CNS E14 (RPKM 29.3) and 22 other tissues See more
Orthologs
all
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Genomic context

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Location:
11 E1; 11 67.64 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (103857551..103876176)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (103966725..103985350)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene N-ethylmaleimide sensitive fusion protein Neighboring gene predicted gene, 35365 Neighboring gene STARR-seq mESC enhancer starr_30866 Neighboring gene CDGSH iron-sulfur domain-containing protein 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_30868 Neighboring gene STARR-seq mESC enhancer starr_30869 Neighboring gene STARR-positive B cell enhancer ABC_E7072 Neighboring gene STARR-positive B cell enhancer ABC_E69 Neighboring gene STARR-seq mESC enhancer starr_30872 Neighboring gene STARR-positive B cell enhancer ABC_E7073 Neighboring gene STARR-positive B cell enhancer mm9_chr11:103862407-103862708 Neighboring gene predicted gene, 35420 Neighboring gene predicted gene, 51921 Neighboring gene predicted gene, 42092

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular mechanism of membrane recruitment of GGA by ARF in lysosomal protein transport. Shiba T, et al. Nat Struct Biol, 2003 May. PMID 12679809
  2. Investigations of the genomic region that contains the clf1 mutation, a causal gene in multifactorial cleft lip and palate in mice. Juriloff DM, et al. Birth Defects Res A Clin Mol Teratol, 2005 Feb. PMID 15690355
  3. Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. Schürmann A, et al. J Biol Chem, 1994 Jun 3. PMID 8195219
  4. Structure and intracellular localization of mouse ADP-ribosylation factors type 1 to type 6 (ARF1-ARF6). Hosaka M, et al. J Biochem, 1996 Oct. PMID 8947846
  5. A digenic cause of cleft lip in A-strain mice and definition of candidate genes for the two loci. Juriloff DM, et al. Birth Defects Res A Clin Mol Teratol, 2004 Aug. PMID 15329828

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding TAS
Traceable Author Statement
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ADP-ribosylation factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304574.1 → NP_001291503.1  ADP-ribosylation factor 2

    See identical proteins and their annotated locations for NP_001291503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK042977, BY129623, BY683617
    Consensus CDS
    CCDS25525.1
    UniProtKB/Swiss-Prot
    Q3TJ37, Q8BSL7, Q91VR9
    Related
    ENSMUSP00000051814.4, ENSMUST00000057921.10
    Conserved Domains (1) summary
    cl40481
    Location:1 → 180
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

  2. NM_007477.5 → NP_031503.1  ADP-ribosylation factor 2

    See identical proteins and their annotated locations for NP_031503.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK053123, BY683617
    Consensus CDS
    CCDS25525.1
    UniProtKB/Swiss-Prot
    Q3TJ37, Q8BSL7, Q91VR9
    Related
    ENSMUSP00000102622.3, ENSMUST00000063347.12
    Conserved Domains (1) summary
    cl40481
    Location:1 → 180
    YlqF_related_GTPase; Circularly permuted YlqF-related GTPases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    103857551..103876176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BSL7.2 GenPept UniProtKB/Swiss-Prot:Q8BSL7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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