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Arg1 arginase, liver [ Mus musculus (house mouse) ]

Gene ID: 11846, updated on 20-Jul-2021

Summary

Official Symbol
Arg1provided by MGI
Official Full Name
arginase, liverprovided by MGI
Primary source
MGI:MGI:88070
See related
Ensembl:ENSMUSG00000019987
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI; PG; Arg; PGIF; Arg-1; AI256583
Expression
Biased expression in liver adult (RPKM 207.8) and liver E18 (RPKM 196.5) See more
Orthologs
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Genomic context

See Arg1 in Genome Data Viewer
Location:
10; 10 A4
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (24791105..24803368, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (24915207..24927470, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (24635013..24647276, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 23 Neighboring gene predicted gene, 23410 Neighboring gene microRNA 6905 Neighboring gene predicted gene, 40616 Neighboring gene predicted gene, 36228 Neighboring gene actin, gamma, cytoplasmic 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables arginase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables arginase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables arginase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables manganese ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in arginine catabolic process to ornithine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in arginine catabolic process to ornithine ISO
Inferred from Sequence Orthology
more info
 
involved_in arginine metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in collagen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to protozoan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of T-helper 2 cell cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of activated T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interferon-gamma-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neutrophil mediated killing of fungus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of L-arginine import ISO
Inferred from Sequence Orthology
more info
 
involved_in urea cycle ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
arginase-1
Names
arginase 1, liver
arginase I
liver-type arginase
type I arginase
NP_031508.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007482.3NP_031508.1  arginase-1

    See identical proteins and their annotated locations for NP_031508.1

    Status: VALIDATED

    Source sequence(s)
    AK149471, CB947842, U88541
    Consensus CDS
    CCDS48523.1
    UniProtKB/Swiss-Prot
    Q61176
    Related
    ENSMUSP00000020161.9, ENSMUST00000020161.10
    Conserved Domains (1) summary
    cd11587
    Location:9303
    Arginase-like; Arginase types I and II and arginase-like family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    24791105..24803368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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