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ZNF511 zinc finger protein 511 [ Homo sapiens (human) ]

Gene ID: 118472, updated on 7-Apr-2024

Summary

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Official Symbol
ZNF511provided by HGNC
Official Full Name
zinc finger protein 511provided by HGNC
Primary source
HGNC:HGNC:28445
See related
Ensembl:ENSG00000198546 AllianceGenome:HGNC:28445
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Zfp511
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 11.4), prostate (RPKM 10.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
10q26.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133308914..133313161)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134263351..134267598)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135122418..135126665)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135075828-135076804 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135084013-135084769 Neighboring gene ADAM metallopeptidase domain 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135087865-135088514 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4240 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135089815-135090462 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4242 Neighboring gene tubulin gamma complex component 2 Neighboring gene uncharacterized LOC124902562 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:135106330-135107529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4243 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135122506-135123201 Neighboring gene ZNF511-PRAP1 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135127847-135128348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4246 Neighboring gene calcyon neuron specific vesicular protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135148655-135149330 Neighboring gene BANF1 pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Recognition and suppression of transfected plasmids by protein ZNF511-PRAP1, a potential molecular barrier to transgene expression. Qiu GH, et al. Mol Ther, 2011 Aug. PMID 21540836, Free PMC Article
  2. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  3. Mapping the Genetic Landscape of Human Cells. Horlbeck MA, et al. Cell, 2018 Aug 9. PMID 30033366, Free PMC Article
  4. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Faust TB, et al. Elife, 2018 May 30. PMID 29845934, Free PMC Article
  5. Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers. Rosenbluh J, et al. Cell Syst, 2016 Sep 28. PMID 27684187, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Readthrough ZNF511-PRAP1

Readthrough gene: ZNF511-PRAP1, Included gene: PRAP1

Homology

Clone Names

  • MGC30006

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 511

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145806.4 → NP_665805.2  zinc finger protein 511

    See identical proteins and their annotated locations for NP_665805.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    BC019897, HY179580
    Consensus CDS
    CCDS7677.1
    UniProtKB/Swiss-Prot
    A8K8L5, Q8NB15, Q8WUP1, Q96BV2
    Related
    ENSP00000355251.5, ENST00000361518.10

RNA

  1. NR_130127.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at an internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL530248, BC019897, HY159562, HY179580

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    133308914..133313161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    134263351..134267598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NB15.2 GenPept UniProtKB/Swiss-Prot:Q8NB15

Gene LinkOut

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