Format

Send to:

Choose Destination

Atp1b1 ATPase, Na+/K+ transporting, beta 1 polypeptide [ Mus musculus (house mouse) ]

Gene ID: 11931, updated on 20-Jul-2021

Summary

Official Symbol
Atp1b1provided by MGI
Official Full Name
ATPase, Na+/K+ transporting, beta 1 polypeptideprovided by MGI
Primary source
MGI:MGI:88108
See related
Ensembl:ENSMUSG00000026576
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
At; Atpb; Atp4b; Atpb-1; NKbeta1
Summary
This gene encodes an integral membrane protein that comprises a subunit of an ATP-metabolizing enzyme responsible for transporting sodium and potassium ions across the plasma membrane. This enzyme regulates the electrochemical gradient of these ions in cells, and plays a central role in osmoregulation and signal transmission in nerves and muscles, among other biological processes. The encoded protein is the non-catalytic beta subunit; it works together with a catalytic alpha subunit and a gamma subunit. [provided by RefSeq, Mar 2013]
Expression
Biased expression in cerebellum adult (RPKM 397.4), kidney adult (RPKM 397.3) and 13 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Atp1b1 in Genome Data Viewer
Location:
1 H2.2; 1 71.75 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (164264668..164285924, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (164437099..164458355, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (166367398..166388486, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene basic leucine zipper nuclear factor 1 Neighboring gene NME/NM23 family member 7 Neighboring gene predicted gene, 39690 Neighboring gene predicted gene, 32391 Neighboring gene predicted gene, 39691

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ATPase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ATPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
 
enables P-type sodium:potassium-exchanging transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blastocyst development IMP
Inferred from Mutant Phenotype
more info
 
involved_in cardiac muscle contraction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular potassium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular sodium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular sodium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in membrane repolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in metal ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ATPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of P-type sodium:potassium-exchanging transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of P-type sodium:potassium-exchanging transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium:sodium antiporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of potassium ion import across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sodium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in potassium ion import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cardiac muscle contraction by calcium ion signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in relaxation of cardiac muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion export across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sodium ion export across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion export across plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intercalated disc IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of sodium:potassium-exchanging ATPase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of sodium:potassium-exchanging ATPase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of sodium:potassium-exchanging ATPase complex ISO
Inferred from Sequence Orthology
more info
 
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit beta-1
Names
sodium/potassium ATPase beta subunit
sodium/potassium-dependent ATPase subunit beta-1
NP_033851.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009721.6NP_033851.1  sodium/potassium-transporting ATPase subunit beta-1

    See identical proteins and their annotated locations for NP_033851.1

    Status: REVIEWED

    Source sequence(s)
    AK005071, AK010677, AK160405
    Consensus CDS
    CCDS35755.1
    UniProtKB/Swiss-Prot
    P14094
    UniProtKB/TrEMBL
    Q3TV47, Q545P0
    Related
    ENSMUSP00000027863.8, ENSMUST00000027863.13
    Conserved Domains (1) summary
    TIGR01107
    Location:1304
    Na_K_ATPase_bet; Sodium Potassium ATPase beta subunit

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    164264668..164285924 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center