Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp1b3provided by MGI
Official Full Name: ATPase, Na+/K+ transporting, beta 3 polypeptideprovided by MGI
Primary source: MGI:MGI:107788
See related: Ensembl:ENSMUSG00000032412 AllianceGenome:MGI:107788
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ATPB-3
Summary: Predicted to enable several functions, including ATPase activator activity; ATPase binding activity; and P-type sodium:potassium-exchanging transporter activity. Predicted to be involved in several processes, including cellular monovalent inorganic cation homeostasis; ion transmembrane transport; and positive regulation of cation transmembrane transport. Predicted to act upstream of or within ion transport. Located in cytoplasm. Is expressed in several structures, including early conceptus; heart; hemolymphoid system; nervous system; and sensory organ. Orthologous to human ATP1B3 (ATPase Na+/K+ transporting subunit beta 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 23.7), cerebellum adult (RPKM 12.0) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 50.31 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (96214708..96246368, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (96332655..96364431, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These findings indicate that the beta3 subunit of the Na+,K+-ATPase is a novel determinant of nociceptive sensitivity and further supports the notion that pain variability genes have selective effects on individual pain modalities.(ATP1BETA3, MOUSE)
Title: The beta3 subunit of the Na+,K+-ATPase mediates variable nociceptive sensitivity in the formalin test.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH136202 (e-PCR)
- UniSTS:210197

RH125905 (e-PCR)
- UniSTS:162627

Atp1b3 (e-PCR), detects polymorphism
- UniSTS:480324

NoName (e-PCR)
- UniSTS:487513

D18396 (e-PCR)
- UniSTS:124778

RH143868 (e-PCR)
- UniSTS:233114

NoName (e-PCR)
- UniSTS:236227

RH135902 (e-PCR)
- UniSTS:209900

Atp1b3 (e-PCR), detects polymorphism
- UniSTS:536558

Atp1b3 (e-PCR), detects polymorphism
- UniSTS:536559

RH12662 (e-PCR)
- UniSTS:87279

AW212096 (e-PCR)
- UniSTS:179954

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase activator activity	ISO Inferred from Sequence Orthology more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables P-type sodium:potassium-exchanging transporter activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in metal ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ATP-dependent activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sodium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in potassium ion transport	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of sodium:potassium-exchanging ATPase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of sodium:potassium-exchanging ATPase complex	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/potassium-transporting ATPase subunit beta-3

Names: ATPase, Na+/K+ beta 3 polypeptide; Na K-ATPase beta-3 subunit; sodium/potassium-dependent ATPase subunit beta-3

NP_001344141.1

EC 7.2.2.13

NP_001344142.1

EC 7.2.2.13

NP_001398556.1

EC 7.2.2.13

NP_001398557.1

EC 7.2.2.13

NP_031528.1

EC 7.2.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357212.2 → NP_001344141.1 sodium/potassium-transporting ATPase subunit beta-3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC117248

Conserved Domains (1) summary

cl08255
Location:1 → 242

Na_K-ATPase; Sodium / potassium ATPase beta chain
NM_001357213.2 → NP_001344142.1 sodium/potassium-transporting ATPase subunit beta-3 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AC117248

Conserved Domains (1) summary

cl08255
Location:1 → 221

Na_K-ATPase; Sodium / potassium ATPase beta chain
NM_001411627.1 → NP_001398556.1 sodium/potassium-transporting ATPase subunit beta-3 isoform 3

Status: VALIDATED

Source sequence(s)

AC117248
NM_001411628.1 → NP_001398557.1 sodium/potassium-transporting ATPase subunit beta-3 isoform 3

Status: VALIDATED

Source sequence(s)

AC117248
NM_007502.6 → NP_031528.1 sodium/potassium-transporting ATPase subunit beta-3 isoform 1

See identical proteins and their annotated locations for NP_031528.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC117248

Consensus CDS

CCDS23414.1

UniProtKB/Swiss-Prot

P97370

UniProtKB/TrEMBL

Q544Q7

Related

ENSMUSP00000034983.6, ENSMUST00000034983.7

Conserved Domains (1) summary

cl08255
Location:1 → 278

Na_K-ATPase; Sodium / potassium ATPase beta chain