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Atp5k ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit E [ Mus musculus (house mouse) ]

Gene ID: 11958, updated on 25-Jan-2022

Summary

Official Symbol
Atp5kprovided by MGI
Official Full Name
ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit Eprovided by MGI
Primary source
MGI:MGI:106636
See related
Ensembl:ENSMUSG00000050856 AllianceGenome:MGI:106636
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lfm1; Atp5i; Atp5me; 2610008D24Rik
Summary
Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in mitochondrial ATP synthesis coupled proton transport. Predicted to act upstream of or within ATP biosynthetic process and ion transport. Located in mitochondrion. Is expressed in alimentary system; hemolymphoid system; liver; and urinary system. Orthologous to human ATP5ME (ATP synthase membrane subunit e). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in placenta adult (RPKM 62.8), heart adult (RPKM 59.6) and 27 other tissues See more
Orthologs
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Genomic context

See Atp5k in Genome Data Viewer
Location:
5 F; 5 53.11 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (108581112..108582265, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (108433246..108434399, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (108862272..108863397, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide Neighboring gene predicted gene, 52851 Neighboring gene predicted gene, 34254 Neighboring gene predicted gene, 34319 Neighboring gene major facilitator superfamily domain containing 7A Neighboring gene polycomb group ring finger 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC107302

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables proton transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within ATP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ATP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in ATP synthesis coupled proton transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in mitochondrial ATP synthesis coupled proton transport ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ATP synthase subunit e, mitochondrial
Names
ATP synthase membrane subunit e
ATPase subunit e
NP_031533.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007507.3NP_031533.2  ATP synthase subunit e, mitochondrial

    See identical proteins and their annotated locations for NP_031533.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer, protein-coding transcript.
    Source sequence(s)
    AC158912, BC028438, CO044079
    Consensus CDS
    CCDS39204.1
    UniProtKB/Swiss-Prot
    Q06185
    Related
    ENSMUSP00000051222.10, ENSMUST00000049628.16
    Conserved Domains (1) summary
    pfam05680
    Location:235
    ATP-synt_E; ATP synthase E chain

RNA

  1. NR_154996.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The transcript is being represented as non-protein coding since the putative protein would be only 38 aa long.
    Source sequence(s)
    AC158912, AK011342, CO044079
    Related
    ENSMUST00000118632.2

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    108581112..108582265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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