Atp5me ATP synthase membrane subunit e [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Atp5meprovided by MGI
Official Full Name: ATP synthase membrane subunit eprovided by MGI
Primary source: MGI:MGI:106636
See related: Ensembl:ENSMUSG00000050856 AllianceGenome:MGI:106636
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lfm1; Atp5i; Atp5k; 2610008D24Rik
Summary: Predicted to enable proton transmembrane transporter activity. Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Predicted to be involved in mitochondrial ATP synthesis coupled proton transport. Predicted to act upstream of or within ATP biosynthetic process and ion transport. Located in mitochondrion. Is expressed in alimentary system; hemolymphoid system; liver; and urinary system. Orthologous to human ATP5ME (ATP synthase membrane subunit e). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in placenta adult (RPKM 62.8), heart adult (RPKM 59.6) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 53.11 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (108581112..108582265, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (108433246..108434399, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Atp5k (e-PCR), detects polymorphism
- UniSTS:141134

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables proton transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
contributes_to proton-transporting ATP synthase activity, rotational mechanism	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within ATP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven ATP synthesis	IEA Inferred from Electronic Annotation more info
involved_in proton motive force-driven mitochondrial ATP synthesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
part_of mitochondrial proton-transporting ATP synthase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial proton-transporting ATP synthase complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of proton-transporting ATP synthase complex, coupling factor F(o)	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ATP synthase subunit e, mitochondrial

Names: ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit E; ATPase subunit e

NP_031533.2

EC 3.6.1.14

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007507.3 → NP_031533.2 ATP synthase subunit e, mitochondrial

See identical proteins and their annotated locations for NP_031533.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer, protein-coding transcript.

Source sequence(s)

AC158912, BC028438, CO044079

Consensus CDS

CCDS39204.1

UniProtKB/Swiss-Prot

P70342, Q06185

UniProtKB/TrEMBL

Q5EBI8

Related

ENSMUSP00000051222.10, ENSMUST00000049628.16

Conserved Domains (1) summary

pfam05680
Location:2 → 35

ATP-synt_E; ATP synthase E chain

RNA

NR_154996.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The transcript is being represented as non-protein coding since the putative protein would be only 38 aa long.

Source sequence(s)

AC158912, AK011342, CO044079

Related

ENSMUST00000118632.2