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CPXM2 carboxypeptidase X, M14 family member 2 [ Homo sapiens (human) ]

Gene ID: 119587, updated on 11-Apr-2024

Summary

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Official Symbol
CPXM2provided by HGNC
Official Full Name
carboxypeptidase X, M14 family member 2provided by HGNC
Primary source
HGNC:HGNC:26977
See related
Ensembl:ENSG00000121898 MIM:617348; AllianceGenome:HGNC:26977
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPX2; UNQ676
Summary
Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in peptide metabolic process and protein processing. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in urinary bladder (RPKM 10.5), fat (RPKM 8.3) and 19 other tissues See more
Orthologs
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Genomic context

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See CPXM2 in Genome Data Viewer
Location:
10q26.13
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (123745639..123944104, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (124622492..124821277, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (125505155..125651323, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125425617-125426155 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125426156-125426693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125430545-125431046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125443142-125443642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125443643-125444143 Neighboring gene G protein-coupled receptor 26 Neighboring gene uncharacterized LOC105378532 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125488883-125489382 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125506649-125507630 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125520224-125521126 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125521127-125522029 Neighboring gene uncharacterized LOC105378533 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125541445-125542192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125619193-125619693 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125623194-125623935 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:125625482-125626289 Neighboring gene Sharpr-MPRA regulatory region 15643 Neighboring gene uncharacterized LOC105378534 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:125685728-125686927 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125707945-125708625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:125710066-125710566 Neighboring gene uncharacterized LOC107984128 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_10754 Neighboring gene Neanderthal introgressed variant-containing enhancers experimental_10761 and experimental_10770 Neighboring gene YBX2 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpression of carboxypeptidase X M14 family member 2 predicts an unfavorable prognosis and promotes proliferation and migration of osteosarcoma. Zhao X, et al. Diagn Pathol, 2019 Oct 24. PMID 31651348, Free PMC Article
  2. Overexpression of CPXM2 predicts an unfavorable prognosis and promotes the proliferation and migration of gastric cancer. Niu G, et al. Oncol Rep, 2019 Oct. PMID 31364750, Free PMC Article
  3. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension. Grabowski K, et al. Hypertens Res, 2022 Feb. PMID 34916661, Free PMC Article
  4. Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course. Gil-Varea E, et al. J Neuroinflammation, 2018 Sep 14. PMID 30217166, Free PMC Article
  5. Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer's Disease. Chen YC, et al. Sci Rep, 2016 Nov 2. PMID 27805002, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
    Title: Cpxm2 as a novel candidate for cardiac hypertrophy and failure in hypertension.
  2. imply an active role for Carboxypeptidase X, M14 family member 2 in promoting tumor aggressiveness via epithelial to mesenchymal transition (EMT) modulation in osteosarcoma
    Title: Overexpression of carboxypeptidase X M14 family member 2 predicts an unfavorable prognosis and promotes proliferation and migration of osteosarcoma.
  3. Results imply an active role for CPXM2 in promoting tumor aggressiveness via epithelial to mesenchymal transition (EMT) modulation in GCs.
    Title: Overexpression of CPXM2 predicts an unfavorable prognosis and promotes the proliferation and migration of gastric cancer.
  4. The Genetic variants located in CPXM2 have the potential to modulate disease course in MS patients and may be used as disease activity biomarkers to identify patients with divergent disease courses.
    Title: Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course.
  5. Performance metrics were used to select SNPs in stage 1, which were then genotyped to another dataset (stage 2). Four SNPs (CPXM2 rs2362967, APOC1 rs4420638, ZNF521 rs7230380, and rs12965520) were identified for LOAD by both traditional P-values (without correcting for multiple tests) and performance metrics.
    Title: Performance Metrics for Selecting Single Nucleotide Polymorphisms in Late-onset Alzheimer's Disease.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  7. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study identifies a novel locus at 6q22.1 associated with ulcerative colitis.
EBI GWAS Catalog
Genome-wide association study of smoking behaviours in patients with COPD.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inactive carboxypeptidase-like protein X2
Names
4632435C11Rik
carboxypeptidase Hlo
carboxypeptidase X (M14 family), member 2
carboxypeptidase-like protein X2
cytosolic carboxypeptidase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052814.1 RefSeqGene

    Range
    57288..203456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_198148.3 → NP_937791.2  inactive carboxypeptidase-like protein X2 precursor

    See identical proteins and their annotated locations for NP_937791.2

    Status: VALIDATED

    Source sequence(s)
    AC009987, AY358565
    Consensus CDS
    CCDS7637.1
    UniProtKB/Swiss-Prot
    B4E3Q2, Q8N436
    UniProtKB/TrEMBL
    B4E1X6
    Related
    ENSP00000241305.3, ENST00000241305.4
    Conserved Domains (4) summary
    cd03869
    Location:314 → 639
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:643 → 718
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:138 → 293
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:137 → 292
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    123745639..123944104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017015673.2 → XP_016871162.1  inactive carboxypeptidase-like protein X2 isoform X3

    UniProtKB/TrEMBL
    Q658N0
    Conserved Domains (4) summary
    cd03869
    Location:205 → 530
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:534 → 609
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:29 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:28 → 183
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  2. XM_011539285.3 → XP_011537587.1  inactive carboxypeptidase-like protein X2 isoform X3

    UniProtKB/TrEMBL
    Q658N0
    Conserved Domains (4) summary
    cd03869
    Location:205 → 530
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:534 → 609
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:29 → 184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:28 → 183
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  3. XM_011539286.2 → XP_011537588.1  inactive carboxypeptidase-like protein X2 isoform X4

    UniProtKB/TrEMBL
    B4DU57
    Conserved Domains (4) summary
    cd03869
    Location:87 → 412
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:416 → 491
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:1 → 66
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:1 → 65
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

  4. XM_017015674.2 → XP_016871163.1  inactive carboxypeptidase-like protein X2 isoform X5

    UniProtKB/TrEMBL
    B4DU57

  5. XM_011539283.3 → XP_011537585.1  inactive carboxypeptidase-like protein X2 isoform X2

    UniProtKB/TrEMBL
    B4E1X6
    Conserved Domains (4) summary
    cd03869
    Location:314 → 639
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    smart00231
    Location:138 → 293
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:137 → 292
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
    cl21470
    Location:643 → 674
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain

  6. XM_005269528.4 → XP_005269585.1  inactive carboxypeptidase-like protein X2 isoform X1

    UniProtKB/TrEMBL
    B4E1X6
    Conserved Domains (4) summary
    cd03869
    Location:314 → 639
    M14_CPX_like; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase X subgroup
    cd11308
    Location:643 → 678
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    smart00231
    Location:138 → 293
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain
    cd00057
    Location:137 → 292
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    124622492..124821277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364763.1 → XP_054220738.1  inactive carboxypeptidase-like protein X2 isoform X3

    UniProtKB/TrEMBL
    B4DK28

  2. XM_054364764.1 → XP_054220739.1  inactive carboxypeptidase-like protein X2 isoform X3

    UniProtKB/TrEMBL
    B4DK28

  3. XM_054364765.1 → XP_054220740.1  inactive carboxypeptidase-like protein X2 isoform X4

  4. XM_054364766.1 → XP_054220741.1  inactive carboxypeptidase-like protein X2 isoform X5

  5. XM_054364762.1 → XP_054220737.1  inactive carboxypeptidase-like protein X2 isoform X2

  6. XM_054364761.1 → XP_054220736.1  inactive carboxypeptidase-like protein X2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8N436.3 GenPept UniProtKB/Swiss-Prot:Q8N436

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