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Met MET proto-oncogene, receptor tyrosine kinase [ Arvicola amphibius (Eurasian water vole) ]

Gene ID: 119806540, updated on 11-Apr-2024

Summary

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Gene symbol
Met
Gene description
MET proto-oncogene, receptor tyrosine kinase
See related
EnsemblRapid:ENSAAPG00005004563
Gene type
protein coding
RefSeq status
MODEL
Organism
Arvicola amphibius
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Cricetidae; Arvicolinae; Arvicola
Orthologs
human mouse all
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Genomic context

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See Met in Genome Data Viewer
Location:
chromosome: 2
Exon count:
22
Annotation release Status Assembly Chr Location
101 current mArvAmp1.2 (GCF_903992535.2) 2 NC_052048.2 (165403749..165513683)
100 previous assembly mArvAmp1.1 (GCF_903992535.1) 2 NC_052048.1 (179053633..179163567, complement)

Chromosome 2 - NC_052048.2Genomic Context describing neighboring genes Neighboring gene caveolin 2 Neighboring gene caveolin 1 Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene acanthoscurrin-2-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables semaphorin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in semaphorin-plexin signaling pathway involved in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of semaphorin receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hepatocyte growth factor receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Arvicola amphibius Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mArvAmp1.2

Genomic

  1. NC_052048.2 Reference mArvAmp1.2

    Range
    165403749..165513683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038318315.1 → XP_038174243.1  hepatocyte growth factor receptor

    Related
    ENSAAPP00005005895.1, ENSAAPT00005006449.2
    Conserved Domains (7) summary
    smart00429
    Location:839 → 935
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:658 → 741
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:564 → 657
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:1083 → 1344
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:520 → 554
    PSI; Plexin repeat
    cl15674
    Location:743 → 838
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:25 → 517
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  2. XM_038318317.1 → XP_038174245.1  hepatocyte growth factor receptor

    Conserved Domains (7) summary
    smart00429
    Location:839 → 935
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:658 → 741
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:564 → 657
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:1083 → 1344
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:520 → 554
    PSI; Plexin repeat
    cl15674
    Location:743 → 838
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:25 → 517
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  3. XM_038318316.1 → XP_038174244.1  hepatocyte growth factor receptor

    Conserved Domains (7) summary
    smart00429
    Location:839 → 935
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:658 → 741
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:564 → 657
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:1083 → 1344
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:520 → 554
    PSI; Plexin repeat
    cl15674
    Location:743 → 838
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:25 → 517
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  4. XM_038318318.1 → XP_038174246.1  hepatocyte growth factor receptor

    Conserved Domains (7) summary
    smart00429
    Location:839 → 935
    IPT; ig-like, plexins, transcription factors
    cd01179
    Location:658 → 741
    IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd01180
    Location:564 → 657
    IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
    cd05058
    Location:1083 → 1344
    PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
    pfam01437
    Location:520 → 554
    PSI; Plexin repeat
    cl15674
    Location:743 → 838
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    cl15693
    Location:25 → 517
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
Nucleotide Protein
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