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B2m beta-2 microglobulin [ Mus musculus (house mouse) ]

Gene ID: 12010, updated on 27-Jul-2021

Summary

Official Symbol
B2mprovided by MGI
Official Full Name
beta-2 microglobulinprovided by MGI
Primary source
MGI:MGI:88127
See related
Ensembl:ENSMUSG00000060802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ly-m1; Ly-m11; beta2-; beta2m; beta2-m
Expression
Broad expression in liver adult (RPKM 838.6), mammary gland adult (RPKM 675.3) and 20 other tissues See more
Orthologs
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Genomic context

See B2m in Genome Data Viewer
Location:
2 E5; 2 60.55 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (121978168..121983563)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122147687..122153082)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (121973423..121978818)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 Neighboring gene MAGE family member B3 Neighboring gene eukaryotic translation initiation factor 3, subunit J1 Neighboring gene SPG11, spatacsin vesicle trafficking associated Neighboring gene protein associated with topoisomerase II homolog 2 (yeast) Neighboring gene tripartite motif-containing 69 Neighboring gene telomere repeat binding bouquet formation protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MHC class II protein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within T cell differentiation in thymus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in amyloid fibril formation ISO
Inferred from Sequence Orthology
more info
 
involved_in antibacterial humoral response ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen processing and presentation of endogenous peptide antigen via MHC class I ISO
Inferred from Sequence Orthology
more info
 
involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation of peptide antigen via MHC class I IEA
Inferred from Electronic Annotation
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular defense response TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to iron ion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to iron(III) ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nicotine ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-negative bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to Gram-positive bacterium ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in immunoglobulin production involved in immunoglobulin-mediated immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within iron ion homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within iron ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in learning or memory ISO
Inferred from Sequence Orthology
more info
 
involved_in modulation of age-related behavioral decline IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in modulation of age-related behavioral decline ISO
Inferred from Sequence Orthology
more info
 
involved_in multicellular organism development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of forebrain neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of forebrain neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron projection development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide antigen assembly with MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of T cell cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ferrous iron binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor-mediated endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transferrin receptor binding ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of iron ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to molecule of bacterial origin IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
part_of HFE-transferrin receptor complex ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class I peptide loading complex ISO
Inferred from Sequence Orthology
more info
 
part_of MHC class I protein complex IEA
Inferred from Electronic Annotation
more info
 
part_of MHC class II protein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009735.3NP_033865.2  beta-2-microglobulin precursor

    See identical proteins and their annotated locations for NP_033865.2

    Status: VALIDATED

    Source sequence(s)
    AK019389
    Consensus CDS
    CCDS16654.1
    UniProtKB/Swiss-Prot
    P01887
    Related
    ENSMUSP00000099534.5, ENSMUST00000102476.5
    Conserved Domains (1) summary
    cd05770
    Location:24116
    IgC_beta2m; Class I major histocompatibility complex (MHC) beta2-microglobulin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    121978168..121983563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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