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Bach2 BTB and CNC homology, basic leucine zipper transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 12014, updated on 21-Apr-2024

Summary

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Official Symbol
Bach2provided by MGI
Official Full Name
BTB and CNC homology, basic leucine zipper transcription factor 2provided by MGI
Primary source
MGI:MGI:894679
See related
Ensembl:ENSMUSG00000040270 AllianceGenome:MGI:894679
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E030004N02Rik
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in import into nucleus and negative regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including central nervous system; limb bud; reproductive system; retina; and urinary system. Human ortholog(s) of this gene implicated in immunodeficiency 60. Orthologous to human BACH2 (BTB domain and CNC homolog 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 5.3), CNS E14 (RPKM 5.0) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 A5; 4 14.02 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32238413..32586109)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32238413..32586109)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4615 Neighboring gene STARR-positive B cell enhancer ABC_E7959 Neighboring gene nuclear encoded tRNA glycine 3 (anticodon CCC) Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32345161-32345344 Neighboring gene VISTA enhancer mm720 Neighboring gene STARR-positive B cell enhancer ABC_E7960 Neighboring gene STARR-positive B cell enhancer ABC_E11713 Neighboring gene STARR-positive B cell enhancer ABC_E6157 Neighboring gene STARR-positive B cell enhancer ABC_E1639 Neighboring gene STARR-positive B cell enhancer mm9_chr4:32478184-32478485 Neighboring gene STARR-seq mESC enhancer starr_09864 Neighboring gene VISTA enhancer mm510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:32647355-32647538 Neighboring gene STARR-seq mESC enhancer starr_09865 Neighboring gene STARR-positive B cell enhancer ABC_E6158 Neighboring gene BTB and CNC homology 2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_09866 Neighboring gene gap junction protein, alpha 10 Neighboring gene caspase 8 associated protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Super-killer CTLs are generated by single gene deletion of Bach2. Barton PR, et al. Eur J Immunol, 2022 Nov. PMID 36086884, Free PMC Article
  2. BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens. Contreras A, et al. J Immunol Res, 2022. PMID 36033397, Free PMC Article
  3. Bach2 regulates B cell survival to maintain germinal centers and promote B cell memory. Hu Q, et al. Biochem Biophys Res Commun, 2022 Aug 27. PMID 35716600
  4. Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells. Mouri K, et al. Nat Genet, 2022 May. PMID 35513721, Free PMC Article
  5. Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2. Finney J, et al. J Immunol, 2021 Sep 1. PMID 34389622, Free PMC Article

See all (94) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cutting Edge: Bach2 Integrates Cytokine Signals to Arbitrate Differentiation Decisions between T Follicular Helper and Th17 Lineages.
    Title: Cutting Edge: Bach2 Integrates Cytokine Signals to Arbitrate Differentiation Decisions between T Follicular Helper and Th17 Lineages.
  2. Super-killer CTLs are generated by single gene deletion of Bach2.
    Title: Super-killer CTLs are generated by single gene deletion of Bach2.
  3. The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.
    Title: The transcription factor Bach2 negatively regulates murine natural killer cell maturation and function.
  4. BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens.
    Title: BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens.
  5. Bach2 regulates B cell survival to maintain germinal centers and promote B cell memory.
    Title: Bach2 regulates B cell survival to maintain germinal centers and promote B cell memory.
  6. Bach2 Deficiency Promotes Intestinal Epithelial Regeneration by Accelerating DNA Repair in Intestinal Stem Cells.
    Title: Bach2 Deficiency Promotes Intestinal Epithelial Regeneration by Accelerating DNA Repair in Intestinal Stem Cells.
  7. Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2.
    Title: Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2.
  8. BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8(+) T cells.
    Title: BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8(+) T cells.
  9. BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression.
    Title: BACH2 drives quiescence and maintenance of resting Treg cells to promote homeostasis and cancer immunosuppression.
  10. Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity.
    Title: Bach2 Deficiency Leads to Spontaneous Expansion of IL-4-Producing T Follicular Helper Cells and Autoimmunity.
Submit: New GeneRIF Correction See all GeneRIFs (52)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC117590

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ion binding EXP
Inferred from Experiment
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in primary adaptive immune response involving T cells and B cells ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription regulator protein BACH2
Names
BTB and CNC homolog 2
BTB and CNC homology 2
Transcription regulator protein BACH2 (BTB and CNC homolog 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109661.1 → NP_001103131.1  transcription regulator protein BACH2

    See identical proteins and their annotated locations for NP_001103131.1

    Status: VALIDATED

    Source sequence(s)
    AL831746, BC131642, CX200493
    Consensus CDS
    CCDS51135.1
    UniProtKB/Swiss-Prot
    A2ANU8, A2ANU9, A2RRI0, P97303
    Related
    ENSMUSP00000131592.2, ENSMUST00000171600.2
    Conserved Domains (2) summary
    cd14719
    Location:639 → 709
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    cd18278
    Location:6 → 129
    BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    32238413..32586109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249909.3 → XP_011248211.1  transcription regulator protein BACH2 isoform X2

    See identical proteins and their annotated locations for XP_011248211.1

    UniProtKB/Swiss-Prot
    A2ANU8, A2ANU9, A2RRI0, P97303
    Related
    ENSMUSP00000103815.3, ENSMUST00000108180.9
    Conserved Domains (2) summary
    cd14719
    Location:639 → 709
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    cd18278
    Location:6 → 129
    BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

  2. XM_030253112.2 → XP_030108972.1  transcription regulator protein BACH2 isoform X2

    UniProtKB/Swiss-Prot
    A2ANU8, A2ANU9, A2RRI0, P97303
    Conserved Domains (2) summary
    cd14719
    Location:639 → 709
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    cd18278
    Location:6 → 129
    BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

  3. XM_011249908.4 → XP_011248210.1  transcription regulator protein BACH2 isoform X1

    See identical proteins and their annotated locations for XP_011248210.1

    Conserved Domains (2) summary
    cd14719
    Location:646 → 716
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    cd18278
    Location:13 → 136
    BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

  4. XM_006537566.5 → XP_006537629.1  transcription regulator protein BACH2 isoform X1

    See identical proteins and their annotated locations for XP_006537629.1

    Conserved Domains (2) summary
    cd14719
    Location:646 → 716
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    cd18278
    Location:13 → 136
    BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

  5. XM_030253109.2 → XP_030108969.1  transcription regulator protein BACH2 isoform X1

    Conserved Domains (2) summary
    cd14719
    Location:646 → 716
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    cd18278
    Location:13 → 136
    BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

  6. XM_036163607.1 → XP_036019500.1  transcription regulator protein BACH2 isoform X2

    UniProtKB/Swiss-Prot
    A2ANU8, A2ANU9, A2RRI0, P97303
    Conserved Domains (2) summary
    cd14719
    Location:639 → 709
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    cd18278
    Location:6 → 129
    BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

  7. XM_036163608.1 → XP_036019501.1  transcription regulator protein BACH2 isoform X2

    UniProtKB/Swiss-Prot
    A2ANU8, A2ANU9, A2RRI0, P97303
    Conserved Domains (2) summary
    cd14719
    Location:639 → 709
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    cd18278
    Location:6 → 129
    BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

  8. XM_006537567.5 → XP_006537630.1  transcription regulator protein BACH2 isoform X2

    See identical proteins and their annotated locations for XP_006537630.1

    UniProtKB/Swiss-Prot
    A2ANU8, A2ANU9, A2RRI0, P97303
    Conserved Domains (2) summary
    cd14719
    Location:639 → 709
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    cd18278
    Location:6 → 129
    BTB_POZ_BACH2; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2)

  9. XM_011249910.4 → XP_011248212.1  transcription regulator protein BACH2 isoform X3

    Conserved Domains (1) summary
    cd14719
    Location:522 → 592
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_007521.3: Suppressed sequence

    Description
    NM_007521.3: This RefSeq was permanently suppressed because it represents a poorly supported variant with non-consensus splice sites.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97303.3 GenPept UniProtKB/Swiss-Prot:P97303

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