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Bcl10 B cell leukemia/lymphoma 10 [ Mus musculus (house mouse) ]

Gene ID: 12042, updated on 12-Sep-2021

Summary

Official Symbol
Bcl10provided by MGI
Official Full Name
B cell leukemia/lymphoma 10provided by MGI
Primary source
MGI:MGI:1337994
See related
Ensembl:ENSMUSG00000028191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CLAP; ME10; cE10; BCL-1; CIPER; BCL-10; C81403; CARMEN; AI132454
Expression
Ubiquitous expression in large intestine adult (RPKM 10.2), bladder adult (RPKM 8.8) and 28 other tissues See more
Orthologs
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Genomic context

See Bcl10 in Genome Data Viewer
Location:
3; 3 H2
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (145630017..145640121)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (145924262..145934366)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (145587342..145597247)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17501 Neighboring gene dimethylarginine dimethylaminohydrolase 1 Neighboring gene ribosomal protein L36A, pseudogene 2 Neighboring gene predicted gene, 35187 Neighboring gene RIKEN cDNA 2410004B18 gene Neighboring gene VISTA enhancer mm311

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CARD domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables CARD domain binding ISO
Inferred from Sequence Orthology
more info
 
enables NF-kappaB binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activator activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein kinase B binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase B binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein self-association ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
NOT acts_upstream_of_or_within B cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within T cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
NOT acts_upstream_of_or_within T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in adaptive immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in adaptive immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in antifungal innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell death ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within fibroblast apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immunoglobulin mediated immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in mast cell activation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of mature B cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of T cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of execution phase of apoptosis ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of T cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in response to food ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to fungus IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CBM complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of CBM complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of CBM complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoplasmic microtubule ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of polkadots IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
B-cell lymphoma/leukemia 10
Names
B-cell CLL/lymphoma 10
CARD-containing molecule enhancing NF-kappa-B
CARD-like apoptotic protein
CED-3/ICH-1 prodomain homologous E10-like regulator
cellular homolog of vCARMEN
cellular-E10
mammalian CARD-containing adapter molecule E10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009740.2NP_033870.1  B-cell lymphoma/leukemia 10

    See identical proteins and their annotated locations for NP_033870.1

    Status: VALIDATED

    Source sequence(s)
    AC123684, AK140179, AK150883, BU707261
    Consensus CDS
    CCDS17897.1
    UniProtKB/Swiss-Prot
    Q9Z0H7
    UniProtKB/TrEMBL
    B7ZWE5
    Related
    ENSMUSP00000029842.8, ENSMUST00000029842.9
    Conserved Domains (1) summary
    cd08810
    Location:17100
    CARD_BCL10; Caspase activation and recruitment domain of B-cell lymphoma 10

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    145630017..145640121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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