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Bet1 Bet1 golgi vesicular membrane trafficking protein [ Mus musculus (house mouse) ]

Gene ID: 12068, updated on 5-Mar-2024

Summary

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Official Symbol
Bet1provided by MGI
Official Full Name
Bet1 golgi vesicular membrane trafficking proteinprovided by MGI
Primary source
MGI:MGI:1343104
See related
Ensembl:ENSMUSG00000032757 AllianceGenome:MGI:1343104
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bet-1
Summary
Predicted to enable SNAP receptor activity and syntaxin binding activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Predicted to act upstream of or within vesicle-mediated transport. Located in Golgi membrane. Orthologous to human BET1 (Bet1 golgi vesicular membrane trafficking protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 9.5), liver E18 (RPKM 9.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 A1; 6 1.81 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (4076899..4086930, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (4076899..4086998, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930528H21 gene Neighboring gene guanine nucleotide binding protein (G protein), gamma 11 Neighboring gene STARR-positive B cell enhancer ABC_E11732 Neighboring gene STARR-seq mESC enhancer starr_15007 Neighboring gene STARR-seq mESC enhancer starr_15008 Neighboring gene STARR-seq mESC enhancer starr_15009 Neighboring gene STARR-seq mESC enhancer starr_15010 Neighboring gene 60S acidic ribosomal protein P1-like Neighboring gene KH-type splicing regulatory protein pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mammalian protein (rbet1) homologous to yeast Bet1p is primarily associated with the pre-Golgi intermediate compartment and is involved in vesicular transport from the endoplasmic reticulum to the Golgi apparatus. Zhang T, et al. J Cell Biol, 1997 Dec 1. PMID 9382863, Free PMC Article
  2. Ykt6 forms a SNARE complex with syntaxin 5, GS28, and Bet1 and participates in a late stage in endoplasmic reticulum-Golgi transport. Zhang T, et al. J Biol Chem, 2001 Jul 20. PMID 11323436
  3. Mammalian Bet3 functions as a cytosolic factor participating in transport from the ER to the Golgi apparatus. Loh E, et al. J Cell Sci, 2005 Mar 15. PMID 15728249
  4. Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells. Hay JC, et al. Cell, 1997 Apr 4. PMID 9094723
  5. Deletion of Peg10, an imprinted gene acquired from a retrotransposon, causes early embryonic lethality. Ono R, et al. Nat Genet, 2006 Jan. PMID 16341224

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SNAP receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle fusion with Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle fusion with Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vesicle-mediated transport TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi cis cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
BET1 homolog
Names
blocked early in transport 1 homolog
golgi vesicular membrane-trafficking protein p18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009748.3 → NP_033878.1  BET1 homolog

    See identical proteins and their annotated locations for NP_033878.1

    Status: VALIDATED

    Source sequence(s)
    AC022235, AI429387, AK078796, AV003506, DV052674
    Consensus CDS
    CCDS19895.1
    UniProtKB/Swiss-Prot
    O35623
    UniProtKB/TrEMBL
    Q8BNZ1
    Related
    ENSMUSP00000044877.5, ENSMUST00000049166.5
    Conserved Domains (1) summary
    cd15853
    Location:29 → 87
    SNARE_Bet1; SNARE motif of Bet1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    4076899..4086930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35623.1 GenPept UniProtKB/Swiss-Prot:O35623

Gene LinkOut

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