Bgn biglycan [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bgnprovided by MGI
Official Full Name: biglycanprovided by MGI
Primary source: MGI:MGI:88158
See related: Ensembl:ENSMUSG00000031375 AllianceGenome:MGI:88158
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BG; PGI; DSPG1; PG-S1; SLRR1A
Summary: This gene encodes a small, leucine-rich repeat proteoglycan that plays important roles in bone mineralization and connective tissue metabolism. The encoded preproprotein undergoes post-translational processing during which chondroitin sulfate or dermatan sulfate chains are attached before incorporation into the extracellular matrix. Mice lacking the encoded protein exhibit reduced growth rate and acquire diminished bone mass progressively with age. [provided by RefSeq, Oct 2015]
Expression: Broad expression in bladder adult (RPKM 238.1), lung adult (RPKM 231.1) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.33 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (72527207..72539542)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (73483601..73495936)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neonatal Achilles Tendon Microstructure is Negatively Impacted by Decorin and Biglycan Knockdown After Injury and During Development.
Title: Neonatal Achilles Tendon Microstructure is Negatively Impacted by Decorin and Biglycan Knockdown After Injury and During Development.
Dermal papilla cell-secreted biglycan regulates hair follicle phase transit and regeneration by activating Wnt/beta-catenin.
Title: Dermal papilla cell-secreted biglycan regulates hair follicle phase transit and regeneration by activating Wnt/β-catenin.
Investigating the temporal roles of decorin and biglycan in tendon healing.
Title: Investigating the temporal roles of decorin and biglycan in tendon healing.
Pregnant biglycan knockout mice have altered cardiorenal adaptations and a shorter gestational length, but do not develop a pre-eclamptic phenotype.
Title: Pregnant biglycan knockout mice have altered cardiorenal adaptations and a shorter gestational length, but do not develop a pre-eclamptic phenotype.
Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy.
Title: Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy.
Transcriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birthdagger.
Title: Transcriptomic profiling of fetal membranes of mice deficient in biglycan and decorin as a model of preterm birth†.
Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix.
Title: Biglycan and chondroitin sulfate play pivotal roles in bone toughness via retaining bound water in bone mineral matrix.
OPG-Fc treatment partially rescues low bone mass phenotype in mature Bgn/Fmod deficient mice but is deleterious to the young mouse skeleton.
Title: OPG-Fc treatment partially rescues low bone mass phenotype in mature Bgn/Fmod deficient mice but is deleterious to the young mouse skeleton.
Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties.
Title: Serum amyloid A-containing HDL binds adipocyte-derived versican and macrophage-derived biglycan, reducing its antiinflammatory properties.
Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity.
Title: Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity.

Submit: New GeneRIF Correction See all GeneRIFs (67)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L20276 (e-PCR)
- UniSTS:181299

Bgn (e-PCR), detects polymorphism
- UniSTS:498490

Bgn (e-PCR), detects polymorphism
- UniSTS:531304

Bgn (e-PCR), detects polymorphism
- UniSTS:141175

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine binding	IPI Inferred from Physical Interaction more info	PubMed
enables extracellular matrix binding	IDA Inferred from Direct Assay more info	PubMed
enables extracellular matrix structural constituent conferring compression resistance	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables glycosaminoglycan binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within articular cartilage development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within bone development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular anatomical structure	IDA Inferred from Direct Assay more info	PubMed
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in transport vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: biglycan

Names: bone/cartilage proteoglycan I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411776.1 → NP_001398705.1 biglycan isoform 1 precursor

Status: REVIEWED

Source sequence(s)

AL732461
NM_007542.5 → NP_031568.2 biglycan isoform 2 preproprotein

See identical proteins and their annotated locations for NP_031568.2

Status: REVIEWED

Source sequence(s)

AK164867, AL732461

Consensus CDS

CCDS30204.1

UniProtKB/Swiss-Prot

P28653, Q61355

UniProtKB/TrEMBL

Q3TNY9, Q3UXK8

Related

ENSMUSP00000033741.8, ENSMUST00000033741.15

Conserved Domains (4) summary

smart00013
Location:63 → 95

LRRNT; Leucine rich repeat N-terminal domain

cd00116
Location:96 → 323

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:72 → 92

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:94 → 151

LRR_8; Leucine rich repeat