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OR10P1 olfactory receptor family 10 subfamily P member 1 [ Homo sapiens (human) ]

Gene ID: 121130, updated on 5-Mar-2024

Summary

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Official Symbol
OR10P1provided by HGNC
Official Full Name
olfactory receptor family 10 subfamily P member 1provided by HGNC
Primary source
HGNC:HGNC:15378
See related
Ensembl:ENSG00000175398 AllianceGenome:HGNC:15378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR12-7; OST701; OR10P1P; OR10P2P; OR10P3P
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

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See OR10P1 in Genome Data Viewer
Location:
12q13.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (55636892..55637833)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (55603472..55604413)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56030676..56031617)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATM interactor pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:55984039-55984599 Neighboring gene olfactory receptor family 6 subfamily U member 2 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:56030513-56031014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6450 Neighboring gene olfactory receptor family 10 subfamily AE member 3 pseudogene Neighboring gene proteasome subunit beta 3 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia. Goodbourn PT, et al. Genes Brain Behav, 2014 Feb. PMID 24152035
  2. The finished DNA sequence of human chromosome 12. Scherer SE, et al. Nature, 2006 Mar 16. PMID 16541075
  3. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
  4. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
olfactory receptor 10P1
Names
olfactory receptor 10P2
olfactory receptor 10P3
olfactory receptor OR12-7
olfactory receptor, family 10, subfamily P, member 1 pseudogene
olfactory receptor, family 10, subfamily P, member 2 pseudogene
olfactory receptor, family 10, subfamily P, member 3 pseudogene
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_206899.1 → NP_996782.1  olfactory receptor 10P1

    See identical proteins and their annotated locations for NP_996782.1

    Status: VALIDATED

    Source sequence(s)
    AB065867
    Consensus CDS
    CCDS31828.1
    UniProtKB/Swiss-Prot
    B9EGY4, Q8NGE3
    UniProtKB/TrEMBL
    A0A126GVQ0
    Related
    ENSP00000308082.2, ENST00000309675.3
    Conserved Domains (2) summary
    pfam00001
    Location:41 → 291
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:41 → 305
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    55636892..55637833
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    55603472..55604413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NGE3.1 GenPept UniProtKB/Swiss-Prot:Q8NGE3

Gene LinkOut

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