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Prdm1 PR domain containing 1, with ZNF domain [ Mus musculus (house mouse) ]

Gene ID: 12142, updated on 6-Sep-2021

Summary

Official Symbol
Prdm1provided by MGI
Official Full Name
PR domain containing 1, with ZNF domainprovided by MGI
Primary source
MGI:MGI:99655
See related
Ensembl:ENSMUSG00000038151
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bli; Blim; PRDI-; Blimp1; Blimp-1; PRDI-BF1; ZNFPR1A1; b2b1765C; b2b1765Clo
Expression
Broad expression in placenta adult (RPKM 3.0), subcutaneous fat pad adult (RPKM 1.7) and 20 other tissues See more
Orthologs
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Genomic context

See Prdm1 in Genome Data Viewer
Location:
10 B2; 10 23.24 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (44313170..44404548, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (44437174..44528558, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (44156981..44178493, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene autophagy related 5 Neighboring gene microRNA 1929 Neighboring gene predicted gene, 35028 Neighboring gene predicted gene, 22087 Neighboring gene triosephosphate isomerase 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (17)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables histone deacetylase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within artery morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cardiac septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular developmental process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within eye photoreceptor cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within germ cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within heart valve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intestinal epithelial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within maternal placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within morphogenesis of a branching structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative regulation of B cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
NOT acts_upstream_of_or_within positive regulation of B cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of B cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of NK T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of extrathymic T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of natural killer cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within sebum secreting cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within trophoblast giant cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
PR domain zinc finger protein 1
Names
B lymphocyte induced maturation protein
B lymphocyte-induced maturation protein 1
PR domain-containing protein 1
beta-interferon gene positive regulatory domain I-binding factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007548.4NP_031574.2  PR domain zinc finger protein 1

    See identical proteins and their annotated locations for NP_031574.2

    Status: VALIDATED

    Source sequence(s)
    AC027700, AK133503, AK149344, BE954935
    Consensus CDS
    CCDS23825.2
    UniProtKB/Swiss-Prot
    Q60636
    Related
    ENSMUSP00000101129.3, ENSMUST00000105490.3
    Conserved Domains (5) summary
    smart00317
    Location:99205
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5048
    Location:419686
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:575595
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:573595
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:615640
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    44313170..44404548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512503.4XP_006512566.1  PR domain zinc finger protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006512566.1

    UniProtKB/Swiss-Prot
    Q60636
    Conserved Domains (4) summary
    COG5048
    Location:385652
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:541561
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:581606
    zf-H2C2_2; Zinc-finger double domain
    cd19187
    Location:45173
    PR-SET_PRDM1; PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins
  2. XM_011243109.3XP_011241411.1  PR domain zinc finger protein 1 isoform X4

    See identical proteins and their annotated locations for XP_011241411.1

    UniProtKB/Swiss-Prot
    Q60636
    Conserved Domains (4) summary
    COG5048
    Location:385652
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:541561
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:581606
    zf-H2C2_2; Zinc-finger double domain
    cd19187
    Location:45173
    PR-SET_PRDM1; PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins
  3. XM_036155567.1XP_036011460.1  PR domain zinc finger protein 1 isoform X3

    Conserved Domains (3) summary
    sd00017
    Location:622641
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd19187
    Location:112240
    PR-SET_PRDM1; PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins
    pfam13465
    Location:633658
    zf-H2C2_2; Zinc-finger double domain
  4. XM_006512505.3XP_006512568.1  PR domain zinc finger protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006512568.1

    UniProtKB/Swiss-Prot
    Q60636
    Related
    ENSMUSP00000039248.5, ENSMUST00000039174.11
    Conserved Domains (3) summary
    COG5048
    Location:452719
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:608628
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd19187
    Location:112240
    PR-SET_PRDM1; PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins
  5. XM_006512504.4XP_006512567.1  PR domain zinc finger protein 1 isoform X6

    Conserved Domains (4) summary
    COG5048
    Location:247529
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:418438
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:458483
    zf-H2C2_2; Zinc-finger double domain
    cl40432
    Location:150
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
  6. XM_006512502.5XP_006512565.1  PR domain zinc finger protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q60636
    Related
    ENSMUSP00000151237.2, ENSMUST00000218369.2
    Conserved Domains (4) summary
    COG5048
    Location:434701
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:590610
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:630655
    zf-H2C2_2; Zinc-finger double domain
    cd19187
    Location:94222
    PR-SET_PRDM1; PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins
  7. XM_036155568.1XP_036011461.1  PR domain zinc finger protein 1 isoform X5

    Conserved Domains (4) summary
    sd00017
    Location:589608
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd19187
    Location:79207
    PR-SET_PRDM1; PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins
    pfam00096
    Location:589608
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:600625
    zf-H2C2_2; Zinc-finger double domain
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