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Bmp8a bone morphogenetic protein 8a [ Mus musculus (house mouse) ]

Gene ID: 12163, updated on 11-Apr-2024

Summary

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Official Symbol
Bmp8aprovided by MGI
Official Full Name
bone morphogenetic protein 8aprovided by MGI
Primary source
MGI:MGI:104515
See related
Ensembl:ENSMUSG00000032726 AllianceGenome:MGI:104515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OP2; OP-2; Bmp7r1
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein may play a role in development of the reproductive system. Mice lacking a functional copy of this gene exhibit degeneration of germ cells and the epididymal epithelium. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 4. [provided by RefSeq, Jul 2016]
Expression
Biased expression in small intestine adult (RPKM 17.7), colon adult (RPKM 6.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 57.42 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (123206438..123237045, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (123312645..123343252, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2118 Neighboring gene poly(A) binding protein, cytoplasmic 4 Neighboring gene predicted gene, 25788 Neighboring gene predicted gene, 22154 Neighboring gene STARR-seq mESC enhancer starr_11290 Neighboring gene 3-oxoacid CoA transferase 2A Neighboring gene microtubule-actin crosslinking factor 1 Neighboring gene STARR-seq mESC enhancer starr_11292 Neighboring gene predicted gene 12924 Neighboring gene predicted gene, 31156

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a. Chung D, et al. Mol Cell Endocrinol, 2015 Jan 15. PMID 25451979, Free PMC Article
  2. The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells. Kósa JP, et al. Bone, 2011 May 1. PMID 21277400
  3. Mutation in Bmp7 exacerbates the phenotype of Bmp8a mutants in spermatogenesis and epididymis. Zhao GQ, et al. Dev Biol, 2001 Dec 1. PMID 11784057
  4. The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse. Zhao GQ, et al. Genes Dev, 1996 Jul 1. PMID 8682296
  5. Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs). Cheng H, et al. J Bone Joint Surg Am, 2003 Aug. PMID 12925636

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stromal Fgf10 and Bmp8a serve as potential paracrine factors for estrogen-dependent regulation of epithelial proliferation in the uterus.
    Title: Estrogen mediated epithelial proliferation in the uterus is directed by stromal Fgf10 and Bmp8a.
  2. BMP-8 might be an essential player in bone metabolism, especially in response to glucocorticoids
    Title: The protective role of bone morphogenetic protein-8 in the glucocorticoid-induced apoptosis on bone cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cytokine activity TAS
Traceable Author Statement
more info
 PubMed 
enables growth factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cartilage development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoblast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
bone morphogenetic protein 8A
Names
osteogenic protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256019.1 → NP_001242948.1  bone morphogenetic protein 8A isoform 1 precursor

    See identical proteins and their annotated locations for NP_001242948.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). This isoform (1) may undergo proteolytic processing similar to isoform 2.
    Source sequence(s)
    AK157978, BC052168
    Consensus CDS
    CCDS57293.1
    UniProtKB/TrEMBL
    Q3TZB2, Q80VZ0
    Related
    ENSMUSP00000037779.6, ENSMUST00000040496.6
    Conserved Domains (2) summary
    pfam00019
    Location:298 → 411
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:32 → 248
    TGFb_propeptide; TGF-beta propeptide

  2. NM_007558.3 → NP_031584.1  bone morphogenetic protein 8A isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_031584.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AK157978, BC052168
    Consensus CDS
    CCDS18616.1
    UniProtKB/Swiss-Prot
    P34821
    UniProtKB/TrEMBL
    Q3TZB2
    Related
    ENSMUSP00000099701.4, ENSMUST00000102641.10
    Conserved Domains (2) summary
    pfam00019
    Location:298 → 398
    TGF_beta; Transforming growth factor beta like domain
    pfam00688
    Location:32 → 248
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    123206438..123237045 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34821.1 GenPept UniProtKB/Swiss-Prot:P34821

Gene LinkOut

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