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LOC121832832 Sharpr-MPRA regulatory region 1983 [ Homo sapiens (human) ]

Gene ID: 121832832, updated on 10-Oct-2023

Summary

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Gene symbol
LOC121832832
Gene description
Sharpr-MPRA regulatory region 1983
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as a functional enhancer by the Sharpr-MPRA technique (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in K562 erythroleukemia cells (group: K562 Activating non-DNase unmatched - State 1:Tss, active promoter, TSS/CpG island region). [provided by RefSeq, Jul 2021]
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Genomic context

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Location:
12q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (38099267..38099561)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (38048948..38049242)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (38493069..38493363)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:37996810-37997365 Neighboring gene OCT4 hESC enhancer GRCh37_chr12:37997399-37997900 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:37998014-37998590 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:37999519-38000033 Neighboring gene zinc finger protein 970, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:38017714-38018217 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:38018300-38018834 Neighboring gene NANOG hESC enhancer GRCh37_chr12:38041436-38041937 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:38046134-38046673 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:38047293-38048231 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:38053815-38054366 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:38083766-38084278 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:38123991-38124883 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:38512623-38512817 Neighboring gene clustered mitochondria homolog pseudogene 8 Neighboring gene adenylate kinase 6 pseudogene 2 Neighboring gene uncharacterized LOC107984469 Neighboring gene Sharpr-MPRA regulatory region 3539 Neighboring gene RNA, 5S ribosomal pseudogene 358

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_075907.1 

    Range
    101..395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    38099267..38099561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    38048948..38049242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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