U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC121838569 OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124997398-124997946 [ Homo sapiens (human) ]

Gene ID: 121838569, updated on 10-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
LOC121838569
Gene description
OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124997398-124997946
Gene type
biological region
Feature type(s)
regulatory: enhancer
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This genomic sequence was predicted to be a transcriptional regulatory region based on chromatin state analysis from the ENCODE (ENCyclopedia Of DNA Elements) project. It was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells, where it associates with the OCT4 transcription factor and is marked by the H3K27ac and H3K4me1 histone modifications. A subregion was also validated as an enhancer by Sharpr-MPRA (Systematic high-resolution activation and repression profiling with reporter tiling using massively parallel reporter assays) in HepG2 liver carcinoma cells (group: HepG2 Activating DNase unmatched - State 5:Enh, candidate strong enhancer, open chromatin). [provided by RefSeq, Jan 2023]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
12q
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (124512852..124513400)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (124518219..124518767)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (124997589..124997883)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124828658-124829158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124829159-124829659 Neighboring gene Sharpr-MPRA regulatory region 3491 Neighboring gene nuclear receptor corepressor 2 Neighboring gene microRNA 6880 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124853631-124854132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124866136-124866684 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124866685-124867231 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124868677-124869413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124869414-124870149 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124870150-124870886 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124870887-124871621 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124876499-124877188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124879259-124879948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124879949-124880636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124883733-124884232 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124887188-124887832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124887833-124888476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124896741-124897368 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124897369-124897997 Neighboring gene Sharpr-MPRA regulatory region 11802 Neighboring gene uncharacterized LOC124903044 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124911835-124912374 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124912375-124912913 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124917115-124917722 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124917723-124918330 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7285 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124924727-124925447 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124924007-124924726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124937508-124938346 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5058 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5059 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124947144-124947710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124947711-124948278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7287 Neighboring gene conserved acetylation island sequence 32 enhancer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5060 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124963398-124963907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124964417-124964926 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124964927-124965434 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7288 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124975405-124975905 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124979536-124980495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:124980496-124981454 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:124988989-124990188 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124992013-124992598 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:124992911-124993125 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124993187-124993772 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:124996849-124997397 Neighboring gene uncharacterized LOC105370047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125005559-125006111 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125012056-125013044 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125016945-125017877 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125024060-125024769 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125026984-125027517 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125028586-125029120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125035807-125036625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125040245-125041002 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125042521-125043280 Neighboring gene Sharpr-MPRA regulatory region 1212 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5063 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7293 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125052750-125053610 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125053611-125054471 Neighboring gene Sharpr-MPRA regulatory region 12812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125077891-125078394 Neighboring gene uncharacterized LOC101927436 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7294 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125106212-125107104 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125107105-125107998 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:125117605-125118804 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:125120143-125120783 Neighboring gene Sharpr-MPRA regulatory region 4504 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125130641-125131250 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125136287-125136800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125136801-125137314 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25120 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125158286-125158903 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125160065-125160662 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125161261-125161858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7296 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125169354-125169898 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125169899-125170441 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125172481-125173202 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125179365-125179866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125197387-125198032 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125198033-125198677 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125215664-125216268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:125216269-125216872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125218412-125219186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:125219187-125219961 Neighboring gene uncharacterized LOC124903045

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-scale high-resolution mapping of activating and repressive nucleotides in regulatory regions. Ernst J, et al. Nat Biotechnol, 2016 Nov. PMID 27701403, Free PMC Article
  2. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

Go to the top of the page Help

Other Names

  • Sharpr-MPRA regulatory region 612

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_075932.2 

    Range
    101..649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    124512852..124513400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    124518219..124518767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases