U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MMP12 matrix metallopeptidase 12 [ Panthera leo (lion) ]

Gene ID: 122199832, updated on 22-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
MMP12
Gene description
matrix metallopeptidase 12
See related
EnsemblRapid:ENSPLXG00005009592
Gene type
protein coding
RefSeq status
MODEL
Organism
Panthera leo
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Pantherinae; Panthera
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: D1
Exon count:
10
Annotation release Status Assembly Chr Location
100 current P.leo_Ple1_pat1.1 (GCF_018350215.1) D1 NC_056688.1 (1499721..1512521, complement)

Chromosome D1 - NC_056688.1Genomic Context describing neighboring genes Neighboring gene stromelysin-1 Neighboring gene matrix metallopeptidase 1 Neighboring gene matrix metallopeptidase 13 Neighboring gene defective in cullin neddylation 1 domain containing 5

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_056688.1 Chromosome D1 Reference P.leo_Ple1_pat1.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
macrophage metalloelastase

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Panthera leo Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference P.leo_Ple1_pat1.1 Primary Assembly

Genomic

  1. NC_056688.1 Reference P.leo_Ple1_pat1.1 Primary Assembly

    Range
    1499721..1512521 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042905179.1 → XP_042761113.1  macrophage metalloelastase

    Related
    ENSPLXP00005012173.1, ENSPLXT00005019644.1
    Conserved Domains (3) summary
    cd00094
    Location:283 → 470
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    pfam00413
    Location:110 → 264
    Peptidase_M10; Matrixin
    pfam01471
    Location:27 → 88
    PG_binding_1; Putative peptidoglycan binding domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.