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Bub1b BUB1B, mitotic checkpoint serine/threonine kinase [ Mus musculus (house mouse) ]

Gene ID: 12236, updated on 6-Sep-2021

Summary

Official Symbol
Bub1bprovided by MGI
Official Full Name
BUB1B, mitotic checkpoint serine/threonine kinaseprovided by MGI
Primary source
MGI:MGI:1333889
See related
Ensembl:ENSMUSG00000040084
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
BUBR; BUBR1; AU045529
Expression
Biased expression in CNS E11.5 (RPKM 30.8), liver E14 (RPKM 21.6) and 14 other tissues See more
Orthologs
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Genomic context

See Bub1b in Genome Data Viewer
Location:
2; 2 E5
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (118428684..118472073)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (118598202..118641592)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (118423947..118467328)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene BCL2 modifying factor Neighboring gene eukaryotic translation initiation factor 5A pseudogene Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene ankyrin repeat domain 63

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC36092

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of outer kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
part_of outer kinetochore ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in spindle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Names
MAD3/BUB1-related protein kinase
budding uninhibited by benzimidazoles 1 beta
budding uninhibited by benzimidazoles 1 homolog, beta
mitotic checkpoint kinase MAD3L
NP_033903.2
XP_006498685.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009773.3NP_033903.2  mitotic checkpoint serine/threonine-protein kinase BUB1 beta

    See identical proteins and their annotated locations for NP_033903.2

    Status: VALIDATED

    Source sequence(s)
    AK133909, AV315589, BU054510, BY013487
    Consensus CDS
    CCDS16579.1
    UniProtKB/Swiss-Prot
    Q9Z1S0
    UniProtKB/TrEMBL
    Q3UZD6
    Related
    ENSMUSP00000037126.8, ENSMUST00000038341.8
    Conserved Domains (3) summary
    COG0515
    Location:825909
    SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
    pfam08311
    Location:51172
    Mad3_BUB1_I; Mad3/BUB1 homology region 1
    cl21453
    Location:7391035
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    118428684..118472073
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498622.4XP_006498685.1  mitotic checkpoint serine/threonine-protein kinase BUB1 beta isoform X1

    Conserved Domains (3) summary
    TIGR01645
    Location:253445
    half-pint; poly-U binding splicing factor, half-pint family
    pfam08311
    Location:51172
    Mad3_BUB1_I; Mad3/BUB1 homology region 1
    cl21453
    Location:7401036
    PKc_like; Protein Kinases, catalytic domain
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