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C1qc complement component 1, q subcomponent, C chain [ Mus musculus (house mouse) ]

Gene ID: 12262, updated on 5-Jan-2022

Summary

Official Symbol
C1qcprovided by MGI
Official Full Name
complement component 1, q subcomponent, C chainprovided by MGI
Primary source
MGI:MGI:88225
See related
Ensembl:ENSMUSG00000036896
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adib; C1qg; Ciqc; AI385742
Summary
Involved in synapse pruning. Located in postsynapse. Is expressed in blood vessel and retina. Orthologous to human C1QC (complement C1q C chain). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in spleen adult (RPKM 175.9), mammary gland adult (RPKM 135.8) and 22 other tissues See more
Orthologs
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Genomic context

See C1qc in Genome Data Viewer
Location:
4 D3; 4 69.05 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136617112..136620242, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136889801..136892936, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (136445717..136448829, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene Eph receptor B2 Neighboring gene predicted gene, 31536 Neighboring gene complement component 1, q subcomponent, beta polypeptide Neighboring gene complement component 1, q subcomponent, alpha polypeptide Neighboring gene Eph receptor A8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in complement activation, classical pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of granulocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of macrophage differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in synapse pruning IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
 
part_of complement component C1q complex ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space HDA PubMed 
located_in postsynapse IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
complement C1q subcomponent subunit C
Names
adiponectin b
complement component 1, q subcomponent, c polypeptide
complement component 1, q subcomponent, gamma polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007574.2NP_031600.2  complement C1q subcomponent subunit C precursor

    See identical proteins and their annotated locations for NP_031600.2

    Status: VALIDATED

    Source sequence(s)
    AI385742, BB636871, CK332232
    Consensus CDS
    CCDS18811.1
    UniProtKB/Swiss-Prot
    Q02105
    Related
    ENSMUSP00000036747.6, ENSMUST00000046332.6
    Conserved Domains (2) summary
    smart00110
    Location:114246
    C1Q; Complement component C1q domain
    pfam01391
    Location:4492
    Collagen; Collagen triple helix repeat (20 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    136617112..136620242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319927.3XP_017175416.1  complement C1q subcomponent subunit C isoform X1

    UniProtKB/Swiss-Prot
    Q02105
    Conserved Domains (2) summary
    smart00110
    Location:114246
    C1Q; Complement component C1q domain
    pfam01391
    Location:4492
    Collagen; Collagen triple helix repeat (20 copies)
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