C1qc complement component 1, q subcomponent, C chain [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C1qcprovided by MGI
Official Full Name: complement component 1, q subcomponent, C chainprovided by MGI
Primary source: MGI:MGI:88225
See related: Ensembl:ENSMUSG00000036896 AllianceGenome:MGI:88225
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Adib; C1qg; Ciqc
Summary: Involved in synapse pruning. Located in postsynapse. Is expressed in blood vessel and retina. Orthologous to human C1QC (complement C1q C chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen adult (RPKM 175.9), mammary gland adult (RPKM 135.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 D3; 4 69.05 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (136617115..136620225, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (136889801..136892936, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of the molecular mechanisms for synchronized transcription of three complement C1q subunit genes (A, B and C) in dendritic cells and macrophages
Title: Molecular mechanisms for synchronized transcription of three complement C1q subunit genes in dendritic cells and macrophages.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

X66295 (e-PCR)
- UniSTS:159317

AI385742 (e-PCR)
- UniSTS:179093

Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in complement activation, classical pathway	ISO Inferred from Sequence Orthology more info
involved_in complement activation, classical pathway	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of granulocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in synapse pruning	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
part_of complement component C1 complex	NAS Non-traceable Author Statement more info	PubMed
part_of complement component C1q complex	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular space	HDA more info	PubMed
is_active_in extrinsic component of postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in extrinsic component of presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in postsynapse	IGI Inferred from Genetic Interaction more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IGI Inferred from Genetic Interaction more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement C1q subcomponent subunit C

Names: adiponectin b; complement component 1, q subcomponent, c polypeptide; complement component 1, q subcomponent, gamma polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001419959.1 → NP_001406888.1 complement C1q subcomponent subunit C precursor

Status: VALIDATED

Source sequence(s)

AL627214

UniProtKB/Swiss-Prot

Q02105, Q6DI63
NM_007574.3 → NP_031600.2 complement C1q subcomponent subunit C precursor

See identical proteins and their annotated locations for NP_031600.2

Status: VALIDATED

Source sequence(s)

AL627214

Consensus CDS

CCDS18811.1

UniProtKB/Swiss-Prot

Q02105, Q6DI63

UniProtKB/TrEMBL

A0A3B0INZ4

Related

ENSMUSP00000036747.6, ENSMUST00000046332.6

Conserved Domains (2) summary

smart00110
Location:114 → 246

C1Q; Complement component C1q domain

pfam01391
Location:44 → 92

Collagen; Collagen triple helix repeat (20 copies)