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Anxa2 annexin A2 [ Mus musculus (house mouse) ]

Gene ID: 12306, updated on 5-Jan-2022

Summary

Official Symbol
Anxa2provided by MGI
Official Full Name
annexin A2provided by MGI
Primary source
MGI:MGI:88246
See related
Ensembl:ENSMUSG00000032231
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cal1h; AW215814
Summary
Predicted to enable several functions, including enzyme binding activity; enzyme inhibitor activity; and phospholipid binding activity. Involved in several processes, including negative regulation of low-density lipoprotein particle receptor catabolic process; positive regulation of low-density lipoprotein particle clearance; and positive regulation of low-density lipoprotein particle receptor binding activity. Acts upstream of or within several processes, including angiogenesis; collagen fibril organization; and fibrinolysis. Located in several cellular components, including Schmidt-Lanterman incisure; basolateral plasma membrane; and myelin sheath adaxonal region. Is extrinsic component of plasma membrane. Is expressed in several structures, including central nervous system; dorsal aorta; oral epithelium; primary palate; and yolk sac blood vessel. Human ortholog(s) of this gene implicated in osteonecrosis. Orthologous to several human genes including ANXA2 (annexin A2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in large intestine adult (RPKM 323.7), genital fat pad adult (RPKM 314.4) and 24 other tissues See more
Orthologs
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Genomic context

See Anxa2 in Genome Data Viewer
Location:
9 C; 9 38.58 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (69360965..69399074)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (69453683..69491792)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (69301490..69339592)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene purine-nucleoside phosphorylase pseudogene Neighboring gene ribosomal protein L7A pseudogene Neighboring gene microRNA 3109 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene predicted gene, 53538

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables S100 protein binding ISO
Inferred from Sequence Orthology
more info
 
enables bone sialoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables phospholipase A2 inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protease binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables virion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in body fluid secretion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to acid chemical IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fibrinolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of low-density lipoprotein particle receptor catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of low-density lipoprotein particle clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of low-density lipoprotein particle receptor binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of low-density lipoprotein receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of receptor recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of receptor-mediated endocytosis involved in cholesterol transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of AnxA2-p11 complex ISO
Inferred from Sequence Orthology
more info
 
part_of PCSK9-AnxA2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
located_in basement membrane IEA
Inferred from Electronic Annotation
more info
 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in collagen-containing extracellular matrix HDA PubMed 
is_active_in cornified envelope IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lipid droplet ISO
Inferred from Sequence Orthology
more info
 
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
 
located_in macropinosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
colocalizes_with membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath adaxonal region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of plasma membrane protein complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of plasma membrane protein complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle ISO
Inferred from Sequence Orthology
more info
 
located_in sarcolemma IDA
Inferred from Direct Assay
more info
PubMed 
located_in stress fiber ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
annexin A2
Names
33-kDa calcimedin
33-kDa lymphocyte Ca<2+>- binding protein
33kDa lymphocyte Ca<2+>- binding protein
36-kDa calelectrin
PAP-IV
annexin II
annexin-2
calpactin I heavy chain
calpactin-1 heavy chain
chromobindin-8
lipocortin II
p36
placental anticoagulant protein IV
protein I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007585.3NP_031611.1  annexin A2

    See identical proteins and their annotated locations for NP_031611.1

    Status: PROVISIONAL

    Source sequence(s)
    CT009708
    Consensus CDS
    CCDS23316.1
    UniProtKB/Swiss-Prot
    P07356
    UniProtKB/TrEMBL
    Q542G9
    Related
    ENSMUSP00000034756.9, ENSMUST00000034756.15
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    69360965..69399074
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510796.3XP_006510859.1  annexin A2 isoform X1

    See identical proteins and their annotated locations for XP_006510859.1

    UniProtKB/Swiss-Prot
    P07356
    UniProtKB/TrEMBL
    Q542G9
    Conserved Domains (1) summary
    pfam00191
    Location:109174
    Annexin
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