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Calm1 calmodulin 1 [ Mus musculus (house mouse) ]

Gene ID: 12313, updated on 5-Jan-2022

Summary

Official Symbol
Calm1provided by MGI
Official Full Name
calmodulin 1provided by MGI
Primary source
MGI:MGI:88251
See related
Ensembl:ENSMUSG00000001175
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CaM; Calm; Cam1; AI256814; AI327027; AI461935; AL024000
Summary
This gene encodes a member of the EF-hand calcium-binding protein family. The encoded protein acts as a calcium sensor and is involved in relaying signals to calcium-sensitive proteins, enzymes and ion channels. The protein-calcium complex binds target proteins to regulate several cellular processes, including smooth muscle contraction, inflammation, apoptosis and the immune response. Mutations in the human gene are associated with catecholaminergic polymorphic ventricular tachycardia and long QT syndrome 14. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Expression
Broad expression in cortex adult (RPKM 432.2), frontal lobe adult (RPKM 376.1) and 26 other tissues See more
Orthologs
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Genomic context

See Calm1 in Genome Data Viewer
Location:
12; 12 E
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (100165694..100176083)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (100199435..100209824)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (101437751..101448016)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36263 Neighboring gene predicted gene 10433 Neighboring gene predicted gene, 40557 Neighboring gene predicted gene 10432 Neighboring gene tetratricopeptide repeat domain 7B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-terminal myristoylation domain binding ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables calcium-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nitric-oxide synthase binding ISO
Inferred from Sequence Orthology
more info
 
enables nitric-oxide synthase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein N-terminus binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables titin binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
enables type 3 metabotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of DAPK1-calmodulin complex ISO
Inferred from Sequence Orthology
more info
 
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
part_of voltage-gated potassium channel complex IGI
Inferred from Genetic Interaction
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calmodulin-1
NP_001300863.1
NP_033920.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313934.1NP_001300863.1  calmodulin-1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC159633, AK145841, AW489089, BC054805
    Consensus CDS
    CCDS83995.1
    UniProtKB/Swiss-Prot
    P0DP26
    UniProtKB/TrEMBL
    Q3UKW2
    Conserved Domains (2) summary
    PTZ00184
    Location:50197
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:133195
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_009790.5NP_033920.1  calmodulin-1 isoform 2

    See identical proteins and their annotated locations for NP_033920.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon resulting in the use of an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC159633, AK150978, AW489089, BC054805, BY294999
    Consensus CDS
    CCDS36523.1
    UniProtKB/Swiss-Prot
    P0DP26, P0DP27, P0DP28
    Related
    ENSMUSP00000105709.4, ENSMUST00000110082.11
    Conserved Domains (1) summary
    PTZ00184
    Location:1149
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    100165694..100176083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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