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Calm2 calmodulin 2 [ Mus musculus (house mouse) ]

Gene ID: 12314, updated on 5-Jan-2022

Summary

Official Symbol
Calm2provided by MGI
Official Full Name
calmodulin 2provided by MGI
Primary source
MGI:MGI:103250
See related
Ensembl:ENSMUSG00000036438
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cam2; CamC; AL024017; 1500001E21Rik
Summary
Enables calcium-dependent protein binding activity. Involved in negative regulation of calcium ion export across plasma membrane and negative regulation of calcium ion transmembrane transporter activity. Acts upstream of or within G2/M transition of mitotic cell cycle and regulation of calcium-mediated signaling. Located in membrane; myelin sheath; and vesicle. Part of voltage-gated potassium channel complex. Is expressed in several structures, including alimentary system; metanephros; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in long QT syndrome 15. Orthologous to human CALM2 (calmodulin 2). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in frontal lobe adult (RPKM 625.9), cortex adult (RPKM 540.2) and 13 other tissues See more
Orthologs
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Genomic context

See Calm2 in Genome Data Viewer
Location:
17; 17 E4
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (87740829..87754363, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (87433401..87446935, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (87832741..87846275, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 7 Neighboring gene uncharacterized LOC102632541 Neighboring gene sperm tail PG rich repeat containing 4 Neighboring gene predicted gene, 26005 Neighboring gene predicted gene, 30794

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-terminal myristoylation domain binding ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables adenylate cyclase binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium channel inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding TAS
Traceable Author Statement
more info
PubMed 
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables titin binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G2/M transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
involved_in detection of calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcium ion export across plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of calcium ion transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ryanodine-sensitive calcium-release channel activity ISO
Inferred from Sequence Orthology
more info
 
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of calcium-mediated signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cardiac muscle contraction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of response to tumor cell ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ryanodine-sensitive calcium-release channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of DAPK1-calmodulin complex ISO
Inferred from Sequence Orthology
more info
 
part_of calcium channel complex ISO
Inferred from Sequence Orthology
more info
 
part_of catalytic complex ISO
Inferred from Sequence Orthology
more info
 
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in myelin sheath IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in sarcomere ISO
Inferred from Sequence Orthology
more info
 
located_in spindle microtubule ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 
part_of voltage-gated potassium channel complex IGI
Inferred from Genetic Interaction
more info
PubMed 
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calmodulin-2
Names
caM
NP_001342632.1
NP_031615.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355703.1NP_001342632.1  calmodulin-2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BY095488, BY663775, CX565080
    Consensus CDS
    CCDS89167.1
    Related
    ENSMUSP00000157025.2, ENSMUST00000234406.2
    Conserved Domains (1) summary
    PTZ00184
    Location:1113
    PTZ00184; calmodulin; Provisional
  2. NM_007589.5NP_031615.1  calmodulin-2 isoform 1

    See identical proteins and their annotated locations for NP_031615.1

    Status: VALIDATED

    Source sequence(s)
    BC100301, BY095488, BY660536
    Consensus CDS
    CCDS37716.1
    UniProtKB/Swiss-Prot
    P0DP26, P0DP27, P0DP28
    Related
    ENSMUSP00000048857.7, ENSMUST00000040440.7
    Conserved Domains (1) summary
    PTZ00184
    Location:1149
    PTZ00184; calmodulin; Provisional

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    87740829..87754363 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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