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Camk2a calcium/calmodulin-dependent protein kinase II alpha [ Mus musculus (house mouse) ]

Gene ID: 12322, updated on 8-Jul-2021

Summary

Official Symbol
Camk2aprovided by MGI
Official Full Name
calcium/calmodulin-dependent protein kinase II alphaprovided by MGI
Primary source
MGI:MGI:88256
See related
Ensembl:ENSMUSG00000024617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CaMKII; R74975; mKIAA0968
Expression
Biased expression in cortex adult (RPKM 365.9) and frontal lobe adult (RPKM 310.4) See more
Orthologs
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Genomic context

See Camk2a in Genome Data Viewer
Location:
18 E1; 18 34.41 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (61058379..61121224)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (60925307..60988152)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (61085286..61147806)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm879 Neighboring gene arylsulfatase i Neighboring gene microRNA 7220 Neighboring gene microRNA 6982 Neighboring gene solute carrier family 6 (neurotransmitter transporter, L-proline), member 7 Neighboring gene caudal type homeobox 1 Neighboring gene predicted gene, 52351

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables glutamate receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in NMDA selective glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in angiotensin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calmodulin dependent kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic spine development ISO
Inferred from Sequence Orthology
more info
 
involved_in ionotropic glutamate receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-threonine autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cardiac muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic neurotransmitter receptor diffusion trapping ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endocannabinoid signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of mitochondrial membrane permeability involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic vesicle docking IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synaptic vesicle docking IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to ischemia IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
part_of calcium- and calmodulin-dependent protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in presynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type II subunit alpha
Names
CaMK II
alpha-CaMKII
caM kinase II subunit alpha
caMK-II subunit alpha
NP_001273738.1
NP_033922.1
NP_803126.1
XP_006525604.1
XP_017173294.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286809.1NP_001273738.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a significant portion of the 5' coding region and initiates translation at an alternate start codon, compared to variant 2. The resulting isoform (3) is shorter and has a distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AK083245, AW490258, BB659027, BC031745, BY713276
    Consensus CDS
    CCDS70898.1
    UniProtKB/Swiss-Prot
    P11798
    UniProtKB/TrEMBL
    F8WHB5
    Related
    ENSMUSP00000048325.7, ENSMUST00000039904.7
    Conserved Domains (1) summary
    pfam08332
    Location:57184
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. NM_009792.3NP_033922.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1 precursor

    See identical proteins and their annotated locations for NP_033922.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a significant portion of the 5' coding region, initiates translation at an alternate start codon, and has an additional internal exon in the coding region, compared to variant 2. The resulting isoform (1) is shorter and has a distinct N-terminus and an additional internal segment, compared to isoform 2.
    Source sequence(s)
    AC124431
    Consensus CDS
    CCDS29277.1
    UniProtKB/Swiss-Prot
    P11798
    Related
    ENSMUSP00000110950.3, ENSMUST00000115295.9
    Conserved Domains (1) summary
    pfam08332
    Location:68195
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  3. NM_177407.4NP_803126.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 2

    See identical proteins and their annotated locations for NP_803126.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) is the longest transcript and encodes the longest isoform (2).
    Source sequence(s)
    AK083245, AW490258, BC031745
    Consensus CDS
    CCDS29276.1
    UniProtKB/Swiss-Prot
    P11798
    Related
    ENSMUSP00000099952.4, ENSMUST00000102888.10
    Conserved Domains (2) summary
    cd14086
    Location:11302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    61058379..61121224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525541.4XP_006525604.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X1

    See identical proteins and their annotated locations for XP_006525604.1

    UniProtKB/TrEMBL
    F8WIS9
    Related
    ENSMUSP00000025519.5, ENSMUST00000025519.11
    Conserved Domains (2) summary
    cd14086
    Location:11302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:357484
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
  2. XM_017317805.2XP_017173294.1  calcium/calmodulin-dependent protein kinase type II subunit alpha isoform X2

    Conserved Domains (2) summary
    cd14086
    Location:11302
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:346473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain
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