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Camk4 calcium/calmodulin-dependent protein kinase IV [ Mus musculus (house mouse) ]

Gene ID: 12326, updated on 27-Jul-2021

Summary

Official Symbol
Camk4provided by MGI
Official Full Name
calcium/calmodulin-dependent protein kinase IVprovided by MGI
Primary source
MGI:MGI:88258
See related
Ensembl:ENSMUSG00000038128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CaM; CaMKI; CaMKIV; AI666733; CaMKIV/Gr; D18Bwg0362e; A430110E23Rik
Expression
Biased expression in cerebellum adult (RPKM 21.8), cortex adult (RPKM 9.3) and 6 other tissues See more
Orthologs
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Genomic context

See Camk4 in Genome Data Viewer
Location:
18 B1; 18 18.15 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (33067995..33328820)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32934941..33195767)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (33098695..33355421)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930455D15 gene Neighboring gene WD repeat domain 36 Neighboring gene RIKEN cDNA 2310026I22 gene Neighboring gene microRNA 6361 Neighboring gene predicted gene, 54015 Neighboring gene StAR-related lipid transfer (START) domain containing 4 Neighboring gene predicted gene, 41683 Neighboring gene predicted gene, 46640

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin-dependent protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
 
involved_in myeloid dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron-neuron synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within nucleocytoplasmic transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in postsynapse to nucleus signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynapse to nucleus signaling pathway IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in postsynapse to nucleus signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein autophosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calcium/calmodulin-dependent protein kinase type IV
Names
CAM kinase-GR
Ca2+/calmodulin-dependent protein kinase type IV/Gr
caMK IV
NP_033923.2
XP_006525606.1
XP_006525607.1
XP_006525609.1
XP_030106157.1
XP_030106158.1
XP_036016846.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009793.3NP_033923.2  calcium/calmodulin-dependent protein kinase type IV

    See identical proteins and their annotated locations for NP_033923.2

    Status: VALIDATED

    Source sequence(s)
    AC114919, BC070420, CJ104330
    Consensus CDS
    CCDS29122.1
    UniProtKB/TrEMBL
    Q8BGR3
    Related
    ENSMUSP00000046539.5, ENSMUST00000042868.6
    Conserved Domains (1) summary
    cd14085
    Location:38331
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    33067995..33328820
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525544.5XP_006525607.1  calcium/calmodulin-dependent protein kinase type IV isoform X2

    See identical proteins and their annotated locations for XP_006525607.1

    UniProtKB/TrEMBL
    Q8BGR3
    Related
    ENSMUSP00000157216.2, ENSMUST00000234654.2
    Conserved Domains (1) summary
    cd14085
    Location:38331
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
  2. XM_030250297.2XP_030106157.1  calcium/calmodulin-dependent protein kinase type IV isoform X2

    Conserved Domains (1) summary
    cd14085
    Location:38331
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
  3. XM_006525543.3XP_006525606.1  calcium/calmodulin-dependent protein kinase type IV isoform X1

    Conserved Domains (1) summary
    cd14085
    Location:66359
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
  4. XM_030250298.2XP_030106158.1  calcium/calmodulin-dependent protein kinase type IV isoform X3

    Conserved Domains (2) summary
    pfam04698
    Location:200251
    Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    cl21453
    Location:1138
    PKc_like; Protein Kinases, catalytic domain
  5. XM_006525546.5XP_006525609.1  calcium/calmodulin-dependent protein kinase type IV isoform X2

    See identical proteins and their annotated locations for XP_006525609.1

    UniProtKB/TrEMBL
    Q8BGR3
    Conserved Domains (1) summary
    cd14085
    Location:38331
    STKc_CaMKIV; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV
  6. XM_036160953.1XP_036016846.1  calcium/calmodulin-dependent protein kinase type IV isoform X3

    Conserved Domains (2) summary
    pfam04698
    Location:200251
    Rab_eff_C; Rab effector MyRIP/melanophilin C-terminus
    cl21453
    Location:1138
    PKc_like; Protein Kinases, catalytic domain
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