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Canx calnexin [ Mus musculus (house mouse) ]

Gene ID: 12330, updated on 23-Jun-2021

Summary

Official Symbol
Canxprovided by MGI
Official Full Name
calnexinprovided by MGI
Primary source
MGI:MGI:88261
See related
Ensembl:ENSMUSG00000020368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CN; Cnx; AI988026; D11Ertd153e; 1110069N15Rik
Expression
Ubiquitous expression in placenta adult (RPKM 118.8), CNS E11.5 (RPKM 79.3) and 26 other tissues See more
Orthologs
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Genomic context

See Canx in Genome Data Viewer
Location:
11 B1.3; 11 30.46 cM
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50184784..50216500, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50293957..50325673, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (50107459..50139175, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene leukotriene C4 synthase Neighboring gene mastermind like transcriptional coactivator 1 Neighboring gene predicted gene, 46280 Neighboring gene predicted gene, 31865 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables apolipoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
enables ionotropic glutamate receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in clathrin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in synaptic vesicle endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquitin-dependent ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in endoplasmic reticulum quality control compartment IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of lumenal side of endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondria-associated endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in smooth endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110499.1NP_001103969.1  calnexin precursor

    See identical proteins and their annotated locations for NP_001103969.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK004422, AK017254, AK084175, AK166649, BB857984, BX632165, BY309447
    Consensus CDS
    CCDS24633.1
    UniProtKB/Swiss-Prot
    P35564
    UniProtKB/TrEMBL
    Q5SUC3
    Related
    ENSMUSP00000137440.2, ENSMUST00000179865.8
    Conserved Domains (1) summary
    pfam00262
    Location:72441
    Calreticulin; Calreticulin family
  2. NM_001110500.1NP_001103970.1  calnexin precursor

    See identical proteins and their annotated locations for NP_001103970.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK004422, AK017254, AK028279, AK165508, BX632165, BY309447
    Consensus CDS
    CCDS24633.1
    UniProtKB/Swiss-Prot
    P35564
    UniProtKB/TrEMBL
    Q5SUC3
    Conserved Domains (1) summary
    pfam00262
    Location:72441
    Calreticulin; Calreticulin family
  3. NM_007597.3NP_031623.1  calnexin precursor

    See identical proteins and their annotated locations for NP_031623.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK004422, AK017254, AK084175, AK166649, BX632165, BY309447
    Consensus CDS
    CCDS24633.1
    UniProtKB/Swiss-Prot
    P35564
    UniProtKB/TrEMBL
    Q5SUC3
    Related
    ENSMUSP00000020637.9, ENSMUST00000020637.9
    Conserved Domains (1) summary
    pfam00262
    Location:72441
    Calreticulin; Calreticulin family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50184784..50216500 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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