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Cap1 cyclase associated actin cytoskeleton regulatory protein 1 [ Mus musculus (house mouse) ]

Gene ID: 12331, updated on 13-Apr-2024

Summary

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Official Symbol
Cap1provided by MGI
Official Full Name
cyclase associated actin cytoskeleton regulatory protein 1provided by MGI
Primary source
MGI:MGI:88262
See related
Ensembl:ENSMUSG00000028656 AllianceGenome:MGI:88262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
The product of this gene plays a role in regulating actin dynamics by binding actin monomers and promoting the turnover of actin filaments. Reduced expression of this gene causes a reduction in actin filament turnover rates, causing multiple defects, including an increase in cell size, stress-fiber alterations, and defects in endocytosis and cell motility. A pseudogene of this gene is found on chromosome 14. Alternative splicing results in multiple transcript variants, but does not affect the protein. [provided by RefSeq, Jul 2014]
Expression
Ubiquitous expression in large intestine adult (RPKM 69.4), thymus adult (RPKM 59.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 57.27 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (122752841..122779869, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (122859048..122886076, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30548 Neighboring gene STARR-seq mESC enhancer starr_11275 Neighboring gene predicted gene 12873 Neighboring gene STARR-seq mESC enhancer starr_11276 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:122504971-122505172 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:122525696-122525897 Neighboring gene STARR-positive B cell enhancer ABC_E2709 Neighboring gene palmitoyl-protein thioesterase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:122549318-122549471 Neighboring gene STARR-seq mESC enhancer starr_11277 Neighboring gene STARR-seq mESC enhancer starr_11278 Neighboring gene STARR-positive B cell enhancer ABC_E3510 Neighboring gene STARR-positive B cell enhancer mm9_chr4:122616319-122616620 Neighboring gene CDC28 protein kinase regulatory subunit 2 pseudogene Neighboring gene MFSD2 lysolipid transporter A, lysophospholipid

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin. Zhou GL, et al. J Cell Sci, 2014 Dec 1. PMID 25315833, Free PMC Article
  2. Mammalian and malaria parasite cyclase-associated proteins catalyze nucleotide exchange on G-actin through a conserved mechanism. Makkonen M, et al. J Biol Chem, 2013 Jan 11. PMID 23184938, Free PMC Article
  3. Cyclase-associated proteins: CAPacity for linking signal transduction and actin polymerization. Hubberstey AV, et al. FASEB J, 2002 Apr. PMID 11919151
  4. Glutathione alters the mode of calcium-mediated regulation of adenylyl cyclase in membranes from mouse brain. Nakamura J, et al. Biochim Biophys Acta, 1997 May 23. PMID 9187244
  5. A complex containing lysine-acetylated actin inhibits the formin INF2. A M, et al. Nat Cell Biol, 2019 May. PMID 30962575, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyclase-associated protein interacts with actin filament barbed ends to promote depolymerization and formin displacement.
    Title: Cyclase-associated protein interacts with actin filament barbed ends to promote depolymerization and formin displacement.
  2. Loss of the actin regulator cyclase-associated protein 1 (CAP1) modestly affects dendritic spine remodeling during synaptic plasticity.
    Title: Loss of the actin regulator cyclase-associated protein 1 (CAP1) modestly affects dendritic spine remodeling during synaptic plasticity.
  3. Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons.
    Title: Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons.
  4. CAP1, a target of miR-144/451, negatively regulates erythroid differentiation and enucleation.
    Title: CAP1, a target of miR-144/451, negatively regulates erythroid differentiation and enucleation.
  5. Results provide evidence for the importance of dynamic actin recycling by CAP1 and cofilin in the asymmetric division of mouse female gametes.
    Title: CAP1-mediated actin cycling via ADF/cofilin proteins is essential for asymmetric division in mouse oocytes.
  6. we purified an INF2 inhibitor from mouse brain tissue, and identified it as a complex of lysine-acetylated actin (KAc-actin) and cyclase-associated protein (CAP). Inhibition of INF2 by CAP-KAc-actin is dependent on the INF2 diaphanous inhibitory domain (DID).
    Title: A complex containing lysine-acetylated actin inhibits the formin INF2.
  7. The structural basis of actin monomer re-charging by CAP1 protein has been reported.
    Title: Structural basis of actin monomer re-charging by cyclase-associated protein.
  8. Phosphorylation regulates CAP1 function through association with cofilin and actin in order to control the actin cytoskeleton.
    Title: Phosphorylation of the cytoskeletal protein CAP1 controls its association with cofilin and actin.
  9. a novel inhibitory interaction between CAP1/Prss8 and nexin-1, opening the search for specific CAP1/Prss8 antagonists that are independent of its catalytic activity
    Title: The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin-1 (PN-1) inhibition.
  10. lkj o hpoi oihl hip oihpo ih
    Title: Structure and mechanism of mouse cyclase-associated protein (CAP1) in regulating actin dynamics.
Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables adenylate cyclase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within ameboidal-type cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in modification of postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in modification of postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cortical actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
adenylyl cyclase-associated protein 1
Names
CAP, adenylate cyclase-associated protein 1
adenylyl cyclase-associated CAP protein, yeast homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301067.2 → NP_001287996.1  adenylyl cyclase-associated protein 1

    See identical proteins and their annotated locations for NP_001287996.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a 474 aa protein. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AK053351, AK137222, AK171388, DN175073
    Consensus CDS
    CCDS18604.1
    UniProtKB/Swiss-Prot
    P40124, Q8BPT7
    UniProtKB/TrEMBL
    Q3UVJ2
    Related
    ENSMUSP00000068260.6, ENSMUST00000069533.12
    Conserved Domains (2) summary
    pfam01213
    Location:5 → 61
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318 → 472
    CAP_C; Adenylate cyclase associated (CAP) C terminal

  2. NM_001358035.1 → NP_001344964.1  adenylyl cyclase-associated protein 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AK053351, AK137222, DN175073
    Consensus CDS
    CCDS18604.1
    UniProtKB/Swiss-Prot
    P40124, Q8BPT7
    UniProtKB/TrEMBL
    Q3UVJ2
    Related
    ENSMUSP00000101864.4, ENSMUST00000106257.10
    Conserved Domains (2) summary
    pfam01213
    Location:5 → 61
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318 → 472
    CAP_C; Adenylate cyclase associated (CAP) C terminal

  3. NM_001358036.1 → NP_001344965.1  adenylyl cyclase-associated protein 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AK053351, AK137222, BY309560, DN175073
    Consensus CDS
    CCDS18604.1
    UniProtKB/Swiss-Prot
    P40124, Q8BPT7
    UniProtKB/TrEMBL
    Q3UVJ2
    Conserved Domains (2) summary
    pfam01213
    Location:5 → 61
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318 → 472
    CAP_C; Adenylate cyclase associated (CAP) C terminal

  4. NM_007598.5 → NP_031624.2  adenylyl cyclase-associated protein 1

    See identical proteins and their annotated locations for NP_031624.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AK053351, AK137222, DN175073
    Consensus CDS
    CCDS18604.1
    UniProtKB/Swiss-Prot
    P40124, Q8BPT7
    UniProtKB/TrEMBL
    Q3UVJ2
    Related
    ENSMUSP00000101862.2, ENSMUST00000106255.8
    Conserved Domains (2) summary
    pfam01213
    Location:5 → 61
    CAP_N; Adenylate cyclase associated (CAP) N terminal
    pfam08603
    Location:318 → 472
    CAP_C; Adenylate cyclase associated (CAP) C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    122752841..122779869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40124.4 GenPept UniProtKB/Swiss-Prot:P40124

Gene LinkOut

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