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Capg capping actin protein, gelsolin like [ Mus musculus (house mouse) ]

Gene ID: 12332, updated on 11-Apr-2024

Summary

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Official Symbol
Capgprovided by MGI
Official Full Name
capping actin protein, gelsolin likeprovided by MGI
Primary source
MGI:MGI:1098259
See related
Ensembl:ENSMUSG00000056737 AllianceGenome:MGI:1098259
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mbh1; gCap39
Summary
Predicted to enable actin filament binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein domain specific binding activity. Acts upstream of or within cell projection assembly and cellular response to interferon-gamma. Located in phagocytic vesicle. Is expressed in several structures, including alimentary system epithelium; central nervous system; jaw; sensory organ; and urinary system. Orthologous to human CAPG (capping actin protein, gelsolin like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 25.9), bladder adult (RPKM 25.4) and 19 other tissues See more
Orthologs
human all
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Genomic context

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See Capg in Genome Data Viewer
Location:
6 C1; 6 32.27 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (72515265..72539966)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (72538282..72562983)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6440 Neighboring gene methionine adenosyltransferase 2A Neighboring gene promoter of Mat2a antisense radiation induced circulating long non-coding RNA Neighboring gene STARR-seq mESC enhancer starr_16285 Neighboring gene STARR-seq mESC enhancer starr_16286 Neighboring gene STARR-seq mESC enhancer starr_16287 Neighboring gene SH2 domain containing 6 Neighboring gene STARR-positive B cell enhancer ABC_E11320 Neighboring gene STARR-seq mESC enhancer starr_16289 Neighboring gene STARR-positive B cell enhancer ABC_E6442 Neighboring gene ELMO/CED-12 domain containing 3 Neighboring gene STARR-positive B cell enhancer ABC_E4833 Neighboring gene retinol saturase (all trans retinol 13,14 reductase)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Super-enhancer-associated gene CAPG promotes AML progression. Ma Q, et al. Commun Biol, 2023 Jun 9. PMID 37296281, Free PMC Article
  2. Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG. Wang X, et al. J Mol Cell Cardiol, 2021 Oct. PMID 34118218, Free PMC Article
  3. CapG(-/-) mice have specific host defense defects that render them more susceptible than CapG(+/+) mice to Listeria monocytogenes infection but not to Salmonella enterica serovar Typhimurium infection. Parikh SS, et al. Infect Immun, 2003 Nov. PMID 14573680, Free PMC Article
  4. gCap39 is a nuclear and cytoplasmic protein. Onoda K, et al. Cell Motil Cytoskeleton, 1993. PMID 8293478
  5. gCap39, a calcium ion- and polyphosphoinositide-regulated actin capping protein. Yu FX, et al. Science, 1990 Dec 7. PMID 2255912

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Super-enhancer-associated gene CAPG promotes AML progression.
    Title: Super-enhancer-associated gene CAPG promotes AML progression.
  2. Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.
    Title: Exogenous extracellular matrix proteins decrease cardiac fibroblast activation in stiffening microenvironment through CAPG.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament capping IEA
Inferred from Electronic Annotation
more info
  
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell projection assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Flemming body ISO
Inferred from Sequence Orthology
more info
  
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
macrophage-capping protein
Names
actin regulatory protein CAP-G
actin-capping protein GCAP39
capping protein (actin filament), gelsolin-like
myc basic motif homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042534.3 → NP_001035999.1  macrophage-capping protein

    See identical proteins and their annotated locations for NP_001035999.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AA289672, AK152818, AK165153, BY155308
    Consensus CDS
    CCDS39516.1
    UniProtKB/TrEMBL
    Q3UJ44, Q99LB4
    Related
    ENSMUSP00000109705.2, ENSMUST00000114071.8
    Conserved Domains (3) summary
    cd11289
    Location:139 → 226
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:247 → 347
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  2. NM_001271395.1 → NP_001258324.1  macrophage-capping protein

    See identical proteins and their annotated locations for NP_001258324.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC154002, AK152818, AK165153, CD551437
    Consensus CDS
    CCDS39516.1
    UniProtKB/TrEMBL
    Q3UJ44, Q99LB4
    Conserved Domains (3) summary
    cd11289
    Location:139 → 226
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:247 → 347
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  3. NM_001271415.1 → NP_001258344.1  macrophage-capping protein

    See identical proteins and their annotated locations for NP_001258344.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AC154002
    Consensus CDS
    CCDS39516.1
    UniProtKB/TrEMBL
    Q3UJ44, Q99LB4
    Related
    ENSMUSP00000109706.2, ENSMUST00000114072.8
    Conserved Domains (3) summary
    cd11289
    Location:139 → 226
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:247 → 347
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

  4. NM_007599.4 → NP_031625.2  macrophage-capping protein

    See identical proteins and their annotated locations for NP_031625.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript. Variants 1, 2, 3 and 4 encode the same protein.
    Source sequence(s)
    AK159577, AK165153, BU696808
    Consensus CDS
    CCDS39516.1
    UniProtKB/TrEMBL
    Q3UJ44, Q99LB4
    Related
    ENSMUSP00000063389.7, ENSMUST00000071044.13
    Conserved Domains (3) summary
    cd11289
    Location:139 → 226
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:247 → 347
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    72515265..72539966
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321370.2 → XP_017176859.1  macrophage-capping protein isoform X1

    UniProtKB/TrEMBL
    Q3UJ44, Q99LB4
    Conserved Domains (3) summary
    cd11289
    Location:139 → 226
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:17 → 120
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:247 → 347
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P24452.2 GenPept UniProtKB/Swiss-Prot:P24452

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