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Capn3 calpain 3 [ Mus musculus (house mouse) ]

Gene ID: 12335, updated on 7-Sep-2021

Summary

Official Symbol
Capn3provided by MGI
Official Full Name
calpain 3provided by MGI
Primary source
MGI:MGI:107437
See related
Ensembl:ENSMUSG00000079110
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca; Lp; p9; Cap; p94; Lp82; Capa3; Capa-3; AI323605
Expression
Biased expression in thymus adult (RPKM 10.1), genital fat pad adult (RPKM 5.2) and 12 other tissues See more
Orthologs
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Genomic context

See Capn3 in Genome Data Viewer
Location:
2 E5; 2 60.31 cM
Exon count:
25
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120294074..120335400)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120463593..120504919)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (120289329..120330655)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene VPS39 HOPS complex subunit Neighboring gene transmembrane protein 87A Neighboring gene glucosidase, alpha; neutral C Neighboring gene RIKEN cDNA 4931402G19 gene Neighboring gene zinc finger protein 106 Neighboring gene synaptosomal-associated protein 23

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Ganc

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium-dependent cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables catalytic activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables ligase regulator activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables sodium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables structural constituent of muscle IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables titin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G1 to G0 transition involved in cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcium-dependent self proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to salt stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in muscle structure development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myofibril assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein sumoylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of satellite cell activation involved in skeletal muscle regeneration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in programmed cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein destabilization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in response to muscle activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in self proteolysis ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium-dependent self proteolysis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
calpain-3
Names
CANP 3
calcium-activated neutral proteinase 3
calpain L3
calpain p94
muscle-specific calcium-activated neutral protease 3
skeletal muscle specific calpain p94
NP_001103231.1
NP_001171270.1
NP_031627.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109761.2NP_001103231.1  calpain-3 isoform b

    See identical proteins and their annotated locations for NP_001103231.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (b) has multiple differences, compared to variant a. The resulting protein (isoform b) is shorter and has a distinct N-terminus when it is compared to isoform a.
    Source sequence(s)
    BB202194, BC090661
    Consensus CDS
    CCDS50680.1
    UniProtKB/TrEMBL
    Q0VGP9
    Related
    ENSMUSP00000028748.7, ENSMUST00000028748.14
    Conserved Domains (5) summary
    cd00051
    Location:585639
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:51347
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:361511
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:616672
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:616705
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  2. NM_001177799.1NP_001171270.1  calpain-3 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (c) lacks several alternate, in-frame coding exons, compared to variant a. The resulting protein (isoform c) is shorter when it is compared to isoform a.
    Source sequence(s)
    AF127766, BB202194, BC090661, BC139790, BY142198, CN664345
    Consensus CDS
    CCDS50679.1
    UniProtKB/Swiss-Prot
    Q64691
    UniProtKB/TrEMBL
    A4QPE6, Q0VGP9
    Related
    ENSMUSP00000106349.2, ENSMUST00000110721.9
    Conserved Domains (5) summary
    cd00051
    Location:605659
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77367
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:381531
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:636692
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:636725
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. NM_007601.3NP_031627.2  calpain-3 isoform a

    See identical proteins and their annotated locations for NP_031627.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (a) is the longest transcript and it encodes the longest protein (isoform a).
    Source sequence(s)
    AL935121, BB202194, BC090661, BC139790, BY142198, CN664345
    Consensus CDS
    CCDS16620.1
    UniProtKB/Swiss-Prot
    Q64691
    UniProtKB/TrEMBL
    A4QPE6, Q0VGP9
    Related
    ENSMUSP00000028749.8, ENSMUST00000028749.15
    Conserved Domains (6) summary
    cd00051
    Location:697751
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:429579
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:728784
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:583653
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:728817
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    120294074..120335400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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