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Car7 carbonic anhydrase 7 [ Mus musculus (house mouse) ]

Gene ID: 12354, updated on 29-May-2021

Summary

Official Symbol
Car7provided by MGI
Official Full Name
carbonic anhydrase 7provided by MGI
Primary source
MGI:MGI:103100
See related
Ensembl:ENSMUSG00000031883
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ca7; AV343731
Expression
Broad expression in cerebellum adult (RPKM 10.1), cortex adult (RPKM 7.5) and 19 other tissues See more
Orthologs
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Genomic context

See Car7 in Genome Data Viewer
Location:
8; 8 D3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105261326..105276979)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (104534694..104550347)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (107064707..107074243)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene telomere repeat binding bouquet formation protein 1 Neighboring gene predicted gene, 22148 Neighboring gene NEDD8 activating enzyme E1 subunit 1 Neighboring gene guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 pseudogene Neighboring gene pyruvate dehyrogenase phosphatase catalytic subunit 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbonate dehydratase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hydro-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
carbonic anhydrase 7
Names
CA-VII
carbonate dehydratase VII
carbonic anhydrase VII
NP_001288093.1
NP_001288094.1
NP_444300.1
XP_006530680.1
XP_006530681.1
XP_030099123.1
XP_030099124.1
XP_036009627.1
XP_036009628.1
XP_036009629.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301164.1NP_001288093.1  carbonic anhydrase 7 isoform b

    See identical proteins and their annotated locations for NP_001288093.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate first exon and uses a downstream translation start site compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC130543, BC094913, BY741075
    Consensus CDS
    CCDS80920.1
    UniProtKB/Swiss-Prot
    Q9ERQ8
    UniProtKB/TrEMBL
    G3XA26
    Related
    ENSMUSP00000125112.2, ENSMUST00000159416.8
    Conserved Domains (1) summary
    cl00012
    Location:1206
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  2. NM_001301165.1NP_001288094.1  carbonic anhydrase 7 isoform b

    See identical proteins and their annotated locations for NP_001288094.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate first exon and uses a downstream translation start site compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC130543, AK144275, BC094913
    Consensus CDS
    CCDS80920.1
    UniProtKB/Swiss-Prot
    Q9ERQ8
    UniProtKB/TrEMBL
    G3XA26, Q3UND9
    Related
    ENSMUSP00000125404.2, ENSMUST00000162761.2
    Conserved Domains (1) summary
    cl00012
    Location:1206
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  3. NM_053070.3NP_444300.1  carbonic anhydrase 7 isoform a.

    See identical proteins and their annotated locations for NP_444300.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer isoform (a).
    Source sequence(s)
    AC130543
    Consensus CDS
    CCDS22581.1
    UniProtKB/Swiss-Prot
    Q9ERQ8
    Related
    ENSMUSP00000052136.5, ENSMUST00000056051.11
    Conserved Domains (1) summary
    cd03149
    Location:27262
    alpha_CA_VII; Carbonic anhydrase alpha, CA isozyme VII_like subgroup. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    105261326..105276979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153734.1XP_036009627.1  carbonic anhydrase 7 isoform X2

    Conserved Domains (1) summary
    cl00012
    Location:50232
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  2. XM_030243263.2XP_030099123.1  carbonic anhydrase 7 isoform X1

    Conserved Domains (1) summary
    cl00012
    Location:70252
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  3. XM_036153735.1XP_036009628.1  carbonic anhydrase 7 isoform X4

    Conserved Domains (1) summary
    cl00012
    Location:2158
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  4. XM_036153736.1XP_036009629.1  carbonic anhydrase 7 isoform X4

    Conserved Domains (1) summary
    cl00012
    Location:2158
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  5. XM_006530617.4XP_006530680.1  carbonic anhydrase 7 isoform X3

    See identical proteins and their annotated locations for XP_006530680.1

    UniProtKB/TrEMBL
    G3XA26
    Conserved Domains (1) summary
    cl00012
    Location:1206
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  6. XM_030243264.1XP_030099124.1  carbonic anhydrase 7 isoform X3

    Conserved Domains (1) summary
    cl00012
    Location:1206
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
  7. XM_006530618.4XP_006530681.1  carbonic anhydrase 7 isoform X3

    See identical proteins and their annotated locations for XP_006530681.1

    UniProtKB/TrEMBL
    G3XA26
    Conserved Domains (1) summary
    cl00012
    Location:1206
    alpha_CA; Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...
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