TMEM266 transmembrane protein 266 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TMEM266provided by HGNC
Official Full Name: transmembrane protein 266provided by HGNC
Primary source: HGNC:HGNC:26763
See related: Ensembl:ENSG00000169758 MIM:618691; AllianceGenome:HGNC:26763
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HVRP1; HsHVRP1; C15orf27; hTMEM266
Summary: Enables protein homodimerization activity. Predicted to be involved in transmembrane transport. Located in cytosol; dendrite; and plasma membrane. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta (RPKM 1.7), testis (RPKM 1.2) and 14 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q24.2

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (76059985..76204963)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (73930701..74075873)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (76352326..76497304)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here the authors show that hTMEM266 forms oligomers, undergoes both rapid (micros) and slow (ms) structural rearrangements in response to changes in voltage, and contains a Zn(2+) binding site that can regulate the slow conformational transition. Our results demonstrate that the S1-S4 domain in hTMEM266 is a functional voltage sensor.
Title: TMEM266 is a functional voltage sensor regulated by extracellular Zn(2).
Results identified HVRP1, a voltage sensing domains-containing protein primarily expressed in the central nervous system with high expression in cerebellar tissues particularly in the granule layer.
Title: Evidence for functional diversity between the voltage-gated proton channel Hv1 and its closest related protein HVRP1.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of chromosome 15 open reading frame 27 (C15orf27) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-112468 (e-PCR)
- UniSTS:182863

SHGC-153295 (e-PCR)
- UniSTS:182890

SHGC-146755 (e-PCR)
- UniSTS:172678

NoName (e-PCR)
- UniSTS:485320

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
NOT enables channel activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables voltage-gated channel activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transmembrane protein 266

Names: Hv1 related protein 1; transmembrane protein C15orf27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152335.5 → NP_689548.3 transmembrane protein 266

Status: VALIDATED

Source sequence(s)

AC091100

Consensus CDS

CCDS10289.2

Related

ENSP00000373594.4, ENST00000388942.9

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

76059985..76204963

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047432151.1 → XP_047288107.1 transmembrane protein 266 isoform X1

UniProtKB/Swiss-Prot

Q2M3C6, Q8N993, Q96LL5
XM_017021915.2 → XP_016877404.1 transmembrane protein 266 isoform X1

UniProtKB/Swiss-Prot

Q2M3C6, Q8N993, Q96LL5

Conserved Domains (1) summary

pfam00520
Location:100 → 218

Ion_trans; Ion transport protein
XM_005254160.4 → XP_005254217.1 transmembrane protein 266 isoform X2

See identical proteins and their annotated locations for XP_005254217.1

UniProtKB/Swiss-Prot

Q2M3C6

Alternate T2T-CHM13v2.0

Genomic

NC_060939.1 Alternate T2T-CHM13v2.0

Range

73930701..74075873

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054377284.1 → XP_054233259.1 transmembrane protein 266 isoform X1

UniProtKB/Swiss-Prot

Q2M3C6, Q8N993, Q96LL5
XM_054377283.1 → XP_054233258.1 transmembrane protein 266 isoform X1

UniProtKB/Swiss-Prot

Q2M3C6, Q8N993, Q96LL5
XM_054377285.1 → XP_054233260.1 transmembrane protein 266 isoform X2