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Casp14 caspase 14 [ Mus musculus (house mouse) ]

Gene ID: 12365, updated on 23-Jun-2021

Summary

Official Symbol
Casp14provided by MGI
Official Full Name
caspase 14provided by MGI
Primary source
MGI:MGI:1335092
See related
Ensembl:ENSMUSG00000005355
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MIC; MICE; mini; mini-ICE
Expression
Biased expression in stomach adult (RPKM 3.3), colon adult (RPKM 1.2) and 2 other tissues See more
Orthologs
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Genomic context

See Casp14 in Genome Data Viewer
Location:
10; 10 C1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (78547829..78554181, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (78711995..78718347, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (78174740..78181038, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 47459 Neighboring gene L-2-hydroxyglutarate dehydrogenase pseudogene Neighboring gene coiled-coil domain containing 105 Neighboring gene predicted gene, 30400 Neighboring gene predicted gene, 53211

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC123948, MGC123949

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables peptidase activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cornification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteolysis RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in keratin filament ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
caspase-14
Names
CASP-14
NP_033939.1
XP_006513223.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009809.5NP_033939.1  caspase-14

    See identical proteins and their annotated locations for NP_033939.1

    Status: VALIDATED

    Source sequence(s)
    AJ007750, AK081645, BY134001
    Consensus CDS
    CCDS23969.1
    UniProtKB/Swiss-Prot
    O89094
    UniProtKB/TrEMBL
    Q542Q1
    Related
    ENSMUSP00000005488.8, ENSMUST00000005488.9
    Conserved Domains (1) summary
    cd00032
    Location:10257
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    78547829..78554181 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513160.4XP_006513223.1  caspase-14 isoform X1

    UniProtKB/Swiss-Prot
    O89094
    Conserved Domains (1) summary
    cl00042
    Location:10140
    CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
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