Casp3 caspase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Casp3provided by MGI
Official Full Name: caspase 3provided by MGI
Primary source: MGI:MGI:107739
See related: Ensembl:ENSMUSG00000031628 AllianceGenome:MGI:107739
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CC3; AC-3; Lice; Yama; mldy; CPP32; SCA-1; CASP-3; CPP-32; Caspase-3; A830040C14Rik
Summary: This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this gene belongs to a subgroup of cysteinyl aspartate-specific proteases that are activated by initiator caspases and that perform the proteolytic cleavage of apoptotic target proteins. Mice defective for this gene exhibit a variety of phenotypes including reduced neuronal apoptosis resulting in hyperplasias, hearing loss, attenuated osteogenic differentiation of bone marrow stromal stem cells, and pre- and post-natal lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression: Broad expression in CNS E18 (RPKM 54.1), CNS E14 (RPKM 37.8) and 16 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 B1.1; 8 26.39 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (47070326..47092733)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (46617291..46639698)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caspase-3 and gasdermin E mediate macrophage pyroptosis in periodontitis.
Title: Caspase-3 and gasdermin E mediate macrophage pyroptosis in periodontitis.
Anti-apoptotic capacity of MALAT1 on hippocampal neurons correlates with CASP3 DNA methylation in a mouse model of autism.
Title: Anti-apoptotic capacity of MALAT1 on hippocampal neurons correlates with CASP3 DNA methylation in a mouse model of autism.
Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore.
Title: Caspase-3 cleaved tau impairs mitochondrial function through the opening of the mitochondrial permeability transition pore.
A Cryptosporidium parvum vaccine candidate effect on immunohistochemical profiling of CD4[+], CD8[+], Caspase-3 and NF-kappaB in mice.
Title: A Cryptosporidium parvum vaccine candidate effect on immunohistochemical profiling of CD4(+), CD8(+), Caspase-3 and NF-κB in mice.
Microglial Caspase-3 is essential for modulating hippocampal neurogenesis.
Title: Microglial Caspase-3 is essential for modulating hippocampal neurogenesis.
Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis.
Title: Study of the roles of caspase-3 and nuclear factor kappa B in myenteric neurons in a P2X7 receptor knockout mouse model of ulcerative colitis.
TXNIP contributes to induction of pro-inflammatory phenotype and caspase-3 activation in astrocytes during Alzheimer's diseases.
Title: TXNIP contributes to induction of pro-inflammatory phenotype and caspase-3 activation in astrocytes during Alzheimer's diseases.
GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy.
Title: GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy.
Preimplantation apoptotic endometrial caspase-3-mediated phospholipase A2 activation: a potential component in programming uterine receptivity.
Title: Preimplantation apoptotic endometrial caspase-3-mediated phospholipase A2 activation: a potential component in programming uterine receptivity.
Intravital molecular imaging reveals that ROS-caspase-3-GSDME-induced cell punching enhances humoral immunotherapy targeting intracellular tumor antigens.
Title: Intravital molecular imaging reveals that ROS-caspase-3-GSDME-induced cell punching enhances humoral immunotherapy targeting intracellular tumor antigens.

Submit: New GeneRIF Correction See all GeneRIFs (291)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (8) 1 citation
Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC316633P1 (e-PCR)
- UniSTS:273022

Casp3 (e-PCR), detects polymorphism
- UniSTS:259200

Casp3 (e-PCR), detects polymorphism
- UniSTS:525205

PMC148819P9 (e-PCR)
- UniSTS:271022

Casp3 (e-PCR), detects polymorphism
- UniSTS:141232

Casp3 (e-PCR), detects polymorphism
- UniSTS:141233

Casp3 (e-PCR), detects polymorphism
- UniSTS:141234

Casp3 (e-PCR), detects polymorphism
- UniSTS:141235

Casp3 (e-PCR), detects polymorphism
- UniSTS:141236

Casp3 (e-PCR), detects polymorphism
- UniSTS:141237

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aspartic-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase inhibitor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity involved in apoptotic process	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type endopeptidase activity involved in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
enables cysteine-type peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type peptidase activity	ISO Inferred from Sequence Orthology more info
enables death receptor binding	ISO Inferred from Sequence Orthology more info
enables endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables enzyme activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables peptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	RCA inferred from Reviewed Computational Analysis more info	PubMed
enables phospholipase A2 activator activity	ISO Inferred from Sequence Orthology more info
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within DNA damage response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior neural tube closure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in axonal fasciculation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to organic substance	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to staurosporine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in erythrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within execution phase of apoptosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within execution phase of apoptosis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in execution phase of apoptosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within fibroblast apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	NAS Non-traceable Author Statement more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to osmotic stress	IDA Inferred from Direct Assay more info	PubMed
involved_in keratinocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within keratinocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in learning or memory	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of activated T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of cyclin-dependent protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytokine production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neurotrophin TRK receptor signaling pathway	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of amyloid-beta formation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pyroptosis	ISO Inferred from Sequence Orthology more info
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein processing	IDA Inferred from Direct Assay more info	PubMed
involved_in protein processing	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	RCA inferred from Reviewed Computational Analysis more info	PubMed
involved_in pyroptosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein stability	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle cycle	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to UV	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to UV	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to glucose	ISO Inferred from Sequence Orthology more info
involved_in response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to organic substance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to wounding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of sound	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
part_of death-inducing signaling complex	IBA Inferred from Biological aspect of Ancestor more info
part_of death-inducing signaling complex	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEP Inferred from Expression Pattern more info	PubMed
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: caspase-3

Names: SREBP cleavage activity 1; apopain; caspase 3, apoptosis related cysteine protease; cysteine protease CPP32; protein Yama

NP_001271338.1

EC 3.4.22.56

NP_033940.1

EC 3.4.22.56

XP_017168032.1

EC 3.4.22.56

XP_030099126.1

EC 3.4.22.56

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001284409.1 → NP_001271338.1 caspase-3

See identical proteins and their annotated locations for NP_001271338.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC119267

Consensus CDS

CCDS22294.1

UniProtKB/Swiss-Prot

O08668, P70677, Q8CHV5, Q9QWI4

Related

ENSMUSP00000147767.2, ENSMUST00000211115.2

Conserved Domains (1) summary

smart00115
Location:37 → 277

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
NM_009810.3 → NP_033940.1 caspase-3

See identical proteins and their annotated locations for NP_033940.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC119267

Consensus CDS

CCDS22294.1

UniProtKB/Swiss-Prot

O08668, P70677, Q8CHV5, Q9QWI4

Related

ENSMUSP00000091238.6, ENSMUST00000093517.7

Conserved Domains (1) summary

smart00115
Location:37 → 277

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

47070326..47092733

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017312543.3 → XP_017168032.1 caspase-3 isoform X1

UniProtKB/Swiss-Prot

O08668, P70677, Q8CHV5, Q9QWI4

Conserved Domains (1) summary

smart00115
Location:37 → 277

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues
XM_030243266.1 → XP_030099126.1 caspase-3 isoform X1

UniProtKB/Swiss-Prot

O08668, P70677, Q8CHV5, Q9QWI4

Conserved Domains (1) summary

smart00115
Location:37 → 277

CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues