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Casr calcium-sensing receptor [ Mus musculus (house mouse) ]

Gene ID: 12374, updated on 16-Oct-2021

Summary

Official Symbol
Casrprovided by MGI
Official Full Name
calcium-sensing receptorprovided by MGI
Primary source
MGI:MGI:1351351
See related
Ensembl:ENSMUSG00000051980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CaR; Gprc2a
Expression
Biased expression in kidney adult (RPKM 6.6) and mammary gland adult (RPKM 0.5) See more
Orthologs
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Genomic context

See Casr in Genome Data Viewer
Location:
16 B3; 16 25.57 cM
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (36310947..36382605, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (36490585..36562141, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (36493782..36562220, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 25903 Neighboring gene stefin A3 Neighboring gene CD86 antigen Neighboring gene predicted gene, 49663 Neighboring gene predicted gene, 41451

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables amino acid binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane transporter binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in bile acid secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in branching morphogenesis of an epithelial tube ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular calcium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in chloride transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
involved_in detection of calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in detection of calcium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in ossification ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of ATPase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of ATPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion import ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
extracellular calcium-sensing receptor
Names
G protein-coupled receptor, family C, group 2, member A
PCaR1
cation sensing receptor
parathyroid cell calcium-sensing receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013803.3NP_038831.2  extracellular calcium-sensing receptor precursor

    See identical proteins and their annotated locations for NP_038831.2

    Status: VALIDATED

    Source sequence(s)
    AC074229, AF110178
    Consensus CDS
    CCDS28154.1
    UniProtKB/Swiss-Prot
    Q9QY96
    Related
    ENSMUSP00000069080.8, ENSMUST00000063597.14
    Conserved Domains (3) summary
    cd15282
    Location:611862
    7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
    cd06364
    Location:33530
    PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:538591
    NCD3G; Nine Cysteines Domain of family 3 GPCR

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    36310947..36382605 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006521730.3XP_006521793.1  extracellular calcium-sensing receptor isoform X1

    See identical proteins and their annotated locations for XP_006521793.1

    UniProtKB/Swiss-Prot
    Q9QY96
    Conserved Domains (3) summary
    cd15282
    Location:611862
    7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
    cd06364
    Location:33530
    PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:538591
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  2. XM_036159757.1XP_036015650.1  extracellular calcium-sensing receptor isoform X1

    Conserved Domains (3) summary
    cd15282
    Location:611862
    7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
    cd06364
    Location:33530
    PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:538591
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  3. XM_006521731.5XP_006521794.1  extracellular calcium-sensing receptor isoform X1

    See identical proteins and their annotated locations for XP_006521794.1

    UniProtKB/Swiss-Prot
    Q9QY96
    Related
    ENSMUSP00000133500.2, ENSMUST00000172826.2
    Conserved Domains (3) summary
    cd15282
    Location:611862
    7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
    cd06364
    Location:33530
    PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:538591
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  4. XM_006521732.3XP_006521795.1  extracellular calcium-sensing receptor isoform X1

    See identical proteins and their annotated locations for XP_006521795.1

    UniProtKB/Swiss-Prot
    Q9QY96
    Conserved Domains (3) summary
    cd15282
    Location:611862
    7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
    cd06364
    Location:33530
    PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:538591
    NCD3G; Nine Cysteines Domain of family 3 GPCR
  5. XM_006521729.3XP_006521792.1  extracellular calcium-sensing receptor isoform X1

    See identical proteins and their annotated locations for XP_006521792.1

    UniProtKB/Swiss-Prot
    Q9QY96
    Conserved Domains (3) summary
    cd15282
    Location:611862
    7tmC_CaSR; calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors
    cd06364
    Location:33530
    PBP1_CaSR; ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    pfam07562
    Location:538591
    NCD3G; Nine Cysteines Domain of family 3 GPCR
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