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Cast calpastatin [ Mus musculus (house mouse) ]

Gene ID: 12380, updated on 28-Nov-2021

Summary

Official Symbol
Castprovided by MGI
Official Full Name
calpastatinprovided by MGI
Primary source
MGI:MGI:1098236
See related
Ensembl:ENSMUSG00000021585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
This gene encodes an inhibitor of the calcium-dependent cysteine protease, calpain. This protein plays roles in multiple processes, including apoptosis, cell cycle regulation, and membrane fusion. Multiple protein isoforms exist which contain unique N-terminal domains, and multiple inhibitory domains that share homology with each other. Some isoforms may be tissue-specific. Two different pseudogenes of this gene are found on chromosome 19. [provided by RefSeq, Jul 2014]
Expression
Broad expression in bladder adult (RPKM 25.7), placenta adult (RPKM 10.2) and 17 other tissues See more
Orthologs
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Genomic context

See Cast in Genome Data Viewer
Location:
13; 13 C1
Exon count:
35
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (74840485..74956993, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (74692366..74808874, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (74831734..74945369, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 431-like Neighboring gene uncharacterized LOC118568073 Neighboring gene predicted gene, 46430 Neighboring gene endoplasmic reticulum aminopeptidase 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene Neighboring gene predicted gene, 30867

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium-dependent cysteine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calcium-dependent cysteine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
calpastatin
Names
calpain inhibitor
calpastatin type III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001301153.1NP_001288082.1  calpastatin isoform 1

    See identical proteins and their annotated locations for NP_001288082.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA033475, AK036576, AK037098, AK083395, BY771015, CF164079, CN529927
    Consensus CDS
    CCDS88491.1
    UniProtKB/Swiss-Prot
    P51125
    UniProtKB/TrEMBL
    Q8CB83
    Related
    ENSMUSP00000152174.2, ENSMUST00000223206.2
    Conserved Domains (1) summary
    pfam00748
    Location:591715
    Calpain_inhib; Calpain inhibitor
  2. NM_001301155.1NP_001288084.1  calpastatin isoform 3

    See identical proteins and their annotated locations for NP_001288084.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (3) with a shorter N-terminus. This variant (3) also uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting protein (isoform 3) has a shorter N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK029293, AK037098, AK083395, CJ072297
    Consensus CDS
    CCDS88490.1
    UniProtKB/TrEMBL
    Q8CE04
    Related
    ENSMUSP00000152118.2, ENSMUST00000223033.2
    Conserved Domains (1) summary
    pfam00748
    Location:231355
    Calpain_inhib; Calpain inhibitor
  3. NM_001301156.1NP_001288085.1  calpastatin isoform 4

    See identical proteins and their annotated locations for NP_001288085.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (4) with a shorter N-terminus. This variant (4) also lacks an internal exon in the coding region. The resulting protein (isoform 4) has a shorter N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK029293, AK037098, AK083310, AK083395, CJ072297
    Consensus CDS
    CCDS88489.1
    UniProtKB/TrEMBL
    Q8C281, Q8CE04
    Related
    ENSMUSP00000152306.2, ENSMUST00000222588.2
    Conserved Domains (1) summary
    pfam00748
    Location:489613
    Calpain_inhib; Calpain inhibitor
  4. NM_001301157.1NP_001288086.1  calpastatin isoform 5

    See identical proteins and their annotated locations for NP_001288086.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (5) with a shorter N-terminus. This variant also lacks two internal exons relative to variant 1. The resulting protein (isoform 5) has a shorter N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK037098, AK083395, BC010603, CJ072297
    Consensus CDS
    CCDS88488.1
    UniProtKB/TrEMBL
    Q921U7
    Related
    ENSMUSP00000152550.2, ENSMUST00000223126.2
    Conserved Domains (1) summary
    pfam00748
    Location:212336
    Calpain_inhib; Calpain inhibitor
  5. NM_001301158.1NP_001288087.1  calpastatin isoform 6

    See identical proteins and their annotated locations for NP_001288087.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (6) with a shorter and distinct N-terminus. This variant (6) also uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting protein (isoform 6) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK006253, AK029293, AK037098, AK083395, BY086784
    Consensus CDS
    CCDS88486.1
    UniProtKB/TrEMBL
    A0A1Y7VJN8, Q8CE04
    Related
    ENSMUSP00000152504.2, ENSMUST00000220738.2
    Conserved Domains (1) summary
    pfam00748
    Location:249372
    Calpain_inhib; Calpain inhibitor
  6. NM_001301160.1NP_001288089.1  calpastatin isoform 7

    See identical proteins and their annotated locations for NP_001288089.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (7) with a shorter N-terminus. The resulting protein (isoform 7) has a shorter and distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK006253, AK029293, AK037098, AK083395, AK161284
    Consensus CDS
    CCDS88487.1
    UniProtKB/Swiss-Prot
    P51125
    UniProtKB/TrEMBL
    Q3TTN2, Q8CE04
    Related
    ENSMUSP00000152657.2, ENSMUST00000223309.2
    Conserved Domains (1) summary
    pfam00748
    Location:234358
    Calpain_inhib; Calpain inhibitor
  7. NM_001301181.1NP_001288110.1  calpastatin isoform 8

    See identical proteins and their annotated locations for NP_001288110.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (8) with a shorter and distinct N-terminus. The resulting protein (isoform 8) has a distinct and shorter N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK006253, AK037098, AK083395, AK161284, BY086784
    UniProtKB/Swiss-Prot
    P51125
    UniProtKB/TrEMBL
    Q3TTN2
    Conserved Domains (1) summary
    pfam00748
    Location:249373
    Calpain_inhib; Calpain inhibitor
  8. NM_009817.4NP_033947.1  calpastatin isoform 2

    See identical proteins and their annotated locations for NP_033947.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at an alternate start codon and result in an isoform (2) with a shorter and distinct N-terminus. This variant also lacks one internal exons relative to variant 1. The resulting protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK028843, AK037098, AK083395, CD550676
    Consensus CDS
    CCDS26648.1
    UniProtKB/TrEMBL
    Q8CE80
    Related
    ENSMUSP00000065275.5, ENSMUST00000065629.6
    Conserved Domains (1) summary
    pfam00748
    Location:557681
    Calpain_inhib; Calpain inhibitor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    74840485..74956993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006517059.1XP_006517122.1  calpastatin isoform X3

    UniProtKB/Swiss-Prot
    P51125
    Conserved Domains (1) summary
    pfam00748
    Location:295419
    Calpain_inhib; Calpain inhibitor
  2. XM_006517056.2XP_006517119.1  calpastatin isoform X1

    Conserved Domains (1) summary
    pfam00748
    Location:314438
    Calpain_inhib; Calpain inhibitor
  3. XM_011244466.4XP_011242768.1  calpastatin isoform X2

    See identical proteins and their annotated locations for XP_011242768.1

    UniProtKB/Swiss-Prot
    P51125
    Conserved Domains (2) summary
    PTZ00449
    Location:23217
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam00748
    Location:299423
    Calpain_inhib; Calpain inhibitor
  4. XM_017315374.1XP_017170863.1  calpastatin isoform X5

    Conserved Domains (1) summary
    pfam00748
    Location:212336
    Calpain_inhib; Calpain inhibitor
  5. XM_011244467.4XP_011242769.1  calpastatin isoform X4

    See identical proteins and their annotated locations for XP_011242769.1

    UniProtKB/Swiss-Prot
    P51125
    Conserved Domains (1) summary
    pfam00748
    Location:231355
    Calpain_inhib; Calpain inhibitor
  6. XM_011244469.4XP_011242771.1  calpastatin isoform X6

    Conserved Domains (1) summary
    pfam00748
    Location:234357
    Calpain_inhib; Calpain inhibitor
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