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Cbx1 chromobox 1 [ Mus musculus (house mouse) ]

Gene ID: 12412, updated on 21-Aug-2019

Summary

Official Symbol
Cbx1provided by MGI
Official Full Name
chromobox 1provided by MGI
Primary source
MGI:MGI:105369
See related
Ensembl:ENSMUSG00000018666
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cbx; M31; HP1B; MOD1; Cbx-rs2; Hp1beta; E430007M08Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 39.9), CNS E14 (RPKM 17.9) and 27 other tissues See more
Orthologs

Genomic context

See Cbx1 in Genome Data Viewer
Location:
11 D; 11 60.11 cM
Exon count:
7
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96788680..96808982)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (96650450..96669954)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene src family associated phosphoprotein 1 Neighboring gene predicted gene, 38960 Neighboring gene sorting nexin 11 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 pseudogene Neighboring gene nuclear factor, erythroid derived 2,-like 1 Neighboring gene microRNA 152 Neighboring gene coatomer protein complex, subunit zeta 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
histone methyltransferase binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
chromatin ISO
Inferred from Sequence Orthology
more info
 
chromocenter IDA
Inferred from Direct Assay
more info
PubMed 
chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
 
female pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
male pronucleus IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with nuclear chromosome, telomeric region ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
pericentric heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
site of DNA damage ISO
Inferred from Sequence Orthology
more info
 
spindle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
chromobox protein homolog 1
Names
chromobox homolog 1
heterochromatin protein 1 homolog beta
heterochromatin protein p25
modifier 1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362560.1NP_001349489.1  chromobox protein homolog 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL596384
    Conserved Domains (2) summary
    cd18650
    Location:2069
    CD_HP1beta_Cbx1; chromodomain of heterochromatin protein 1 homolog beta
    cl28914
    Location:112169
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  2. NM_001362561.1NP_001349490.1  chromobox protein homolog 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL596384
    Conserved Domains (2) summary
    cd18650
    Location:2069
    CD_HP1beta_Cbx1; chromodomain of heterochromatin protein 1 homolog beta
    cl28914
    Location:112169
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  3. NM_001362563.1NP_001349492.1  chromobox protein homolog 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL596384
    Conserved Domains (2) summary
    cd18650
    Location:2069
    CD_HP1beta_Cbx1; chromodomain of heterochromatin protein 1 homolog beta
    cl28914
    Location:112169
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  4. NM_001362564.1NP_001349493.1  chromobox protein homolog 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK017608, AL596384
    Related
    ENSMUSP00000078640.3, ENSMUST00000079702.3
    Conserved Domains (2) summary
    pfam00385
    Location:2770
    Chromo; Chromo (CHRromatin Organisation MOdifier) domain
    cl00044
    Location:111139
    ChSh; Chromo Shadow Domain, found in association with N-terminal chromo (CHRromatin Organization MOdifier) domain; Chromo domains mediate the interaction of the heterochromatin with other heterochromatin proteins, thereby affecting chromatin structure (e.g. ...
  5. NM_007622.4NP_031648.1  chromobox protein homolog 1 isoform 1

    See identical proteins and their annotated locations for NP_031648.1

    Status: VALIDATED

    Source sequence(s)
    AK014215, AL596384
    Consensus CDS
    CCDS25303.1
    UniProtKB/Swiss-Prot
    P83917
    Related
    ENSMUSP00000091475.3, ENSMUST00000093943.9
    Conserved Domains (2) summary
    cd18650
    Location:2069
    CD_HP1beta_Cbx1; chromodomain of heterochromatin protein 1 homolog beta
    cl28914
    Location:112169
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains

RNA

  1. NR_155761.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL596384, BC055290
    Related
    ENSMUST00000134585.7

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000077.6 Reference GRCm38.p6 C57BL/6J

    Range
    96788680..96808982
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314242.2XP_017169731.1  chromobox protein homolog 1 isoform X1

    UniProtKB/Swiss-Prot
    P83917
    Conserved Domains (2) summary
    cd18650
    Location:2069
    CD_HP1beta_Cbx1; chromodomain of heterochromatin protein 1 homolog beta
    cl28914
    Location:112169
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  2. XM_006532102.3XP_006532165.1  chromobox protein homolog 1 isoform X2

    Related
    ENSMUSP00000018810.3, ENSMUST00000018810.9
    Conserved Domains (2) summary
    pfam00385
    Location:2770
    Chromo; Chromo (CHRromatin Organisation MOdifier) domain
    cl00044
    Location:111137
    ChSh; Chromo Shadow Domain, found in association with N-terminal chromo (CHRromatin Organization MOdifier) domain; Chromo domains mediate the interaction of the heterochromatin with other heterochromatin proteins, thereby affecting chromatin structure (e.g. ...

RNA

  1. XR_003949269.1 RNA Sequence

  2. XR_003949267.1 RNA Sequence

  3. XR_003949268.1 RNA Sequence

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