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KRBA2 KRAB-A domain containing 2 [ Homo sapiens (human) ]

Gene ID: 124751, updated on 4-Jul-2021

Summary

Official Symbol
KRBA2provided by HGNC
Official Full Name
KRAB-A domain containing 2provided by HGNC
Primary source
HGNC:HGNC:26989
See related
Ensembl:ENSG00000184619
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in heart (RPKM 2.4), kidney (RPKM 2.0) and 25 other tissues See more
Orthologs
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Genomic context

See KRBA2 in Genome Data Viewer
Location:
17p13.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (8358822..8376704, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8262140..8280022, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 15 Neighboring gene outer dense fiber of sperm tails 4 Neighboring gene uncharacterized LOC100128288 Neighboring gene ribosomal protein L26 Neighboring gene ring finger protein 222

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of KRAB-A domain containing 2 (KRBA2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA integration IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
KRAB-A domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304947.3NP_001291876.1  KRAB-A domain-containing protein 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC135178
    Consensus CDS
    CCDS76951.1
    UniProtKB/Swiss-Prot
    Q6ZNG9
    UniProtKB/TrEMBL
    A8MX02
    Related
    ENSP00000379565.3, ENST00000396267.3
    Conserved Domains (1) summary
    cl21549
    Location:207290
    rve; Integrase core domain
  2. NM_213597.3NP_998762.1  KRAB-A domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_998762.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AK131219, BC024723, DB325438
    Consensus CDS
    CCDS11141.1
    UniProtKB/Swiss-Prot
    Q6ZNG9
    Related
    ENSP00000494883.1, ENST00000643221.1
    Conserved Domains (2) summary
    cd07765
    Location:4275
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    cl21549
    Location:289372
    rve; Integrase core domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    8358822..8376704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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