Ms4a1 membrane-spanning 4-domains, subfamily A, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ms4a1provided by MGI
Official Full Name: membrane-spanning 4-domains, subfamily A, member 1provided by MGI
Primary source: MGI:MGI:88321
See related: Ensembl:ENSMUSG00000024673 AllianceGenome:MGI:88321
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cd20; Ly-44; Ms4a2
Summary: Predicted to enable epidermal growth factor receptor binding activity; identical protein binding activity; and immunoglobulin binding activity. Involved in calcium ion import into cytosol. Acts upstream of or within response to bacterium. Located in external side of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human MS4A1 (membrane spanning 4-domains A1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 13.9), mammary gland adult (RPKM 3.4) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 8.19 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (11227043..11243513, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (11249679..11266149, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our findings indicate that anti-CD20-IFNalpha eradicates B-cell lymphoma by employing tumor cells as antigen-presenting cells to reactivate tumor-infiltrating CD8(+) T cells and synergizing with anti-PD-L1 treatment
Title: Converting Lymphoma Cells into Potent Antigen-Presenting Cells for Interferon-Induced Tumor Regression.
Galectin-1 has a role in driving lymphoma CD20 immunotherapy resistance in a mouse model
Title: Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms.
Results indicate that an antigen-specific B cell response towards intracellular pathogens can be generated during anti-CD20 depletion therapy.
Title: Characterization of the B cell response to Leishmania infection after anti-CD20 B cell depletion.
this study demonstrates a role for CD20 in B cell activation and T-dependent humoral immunity.
Title: Reduced T-dependent humoral immunity in CD20-deficient mice.
CD20 is required for store-operated calcium entry in C2C12 myoblasts.
Title: Expression of CD20 reveals a new store-operated calcium entry modulator in skeletal muscle.
immunization of mice with the CD20 extracellular domain-6 using Freund's or QS-21 adjuvants was shown to exert significant biological effects in vivo with the pronounced depletion of splenic B cells.
Title: A CD20 tandem-epitope immunogen elicits antibody in mice that binds murine cell surface CD20 and depletes splenic B cells in vivo.
type I CD20 antibody cytotoxicity critically depends on Fc receptor ITAM signaling
Title: In vivo cytotoxicity of type I CD20 antibodies critically depends on Fc receptor ITAM signaling.
CD20 deficiency in humans results in impaired T cell-independent antibody responses.
Title: CD20 deficiency in humans results in impaired T cell-independent antibody responses.
involvement of CD20 in calcium influx
Title: CD20 homo-oligomers physically associate with the B cell antigen receptor. Dissociation upon receptor engagement and recruitment of phosphoproteins and calmodulin-binding proteins.
In mice treated with anti-CD20 mAb, development of arthritis was significantly reduced in comparison to control mAb-treated mice
Title: Suppression of proteoglycan-induced arthritis by anti-CD20 B Cell depletion therapy is mediated by reduction in autoantibodies and CD4+ T cell reactivity.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M62541 (e-PCR)
- UniSTS:163609

M62541 (e-PCR)
- UniSTS:160798

AA960661 (e-PCR)
- UniSTS:160801

BE687007 (e-PCR)
- UniSTS:209442

Ms4a1 (e-PCR), detects polymorphism
- UniSTS:498244

NoName (e-PCR)
- UniSTS:225353

Ms4a2 (e-PCR), detects polymorphism
- UniSTS:141274

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables immunoglobulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
involved_in B cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in calcium ion import into cytosol	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of calcium ion import across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in protein tetramerization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in store-operated calcium entry	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B-lymphocyte antigen CD20

Names: B-cell differentiation antigen Ly-44; CD20 antigen; lymphocyte antigen 44; membrane-spanning 4-domains, subfamily A, member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.