Cd22 CD22 antigen [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cd22provided by MGI
Official Full Name: CD22 antigenprovided by MGI
Primary source: MGI:MGI:88322
See related: Ensembl:ENSMUSG00000030577 AllianceGenome:MGI:88322
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lyb8; Lyb-8; A530093D23
Summary: Enables CD4 receptor binding activity; protein phosphatase binding activity; and sialic acid binding activity. Involved in several processes, including negative regulation of calcium-mediated signaling; negative regulation of immunoglobulin production; and regulation of B cell proliferation. Located in external side of plasma membrane and neuronal cell body membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Orthologous to human CD22 (CD22 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 81.5), mammary gland adult (RPKM 20.6) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 19.26 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30564829..30579767, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (30865404..30880342, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Enhanced efficacy of CD19/CD22 bispecific CAR-T cells with EAAAK linker on B-cell malignancies.
Title: Enhanced efficacy of CD19/CD22 bispecific CAR-T cells with EAAAK linker on B-cell malignancies.
CD22 blockade modulates microglia activity to suppress neuroinflammation following intracerebral hemorrhage.
Title: CD22 blockade modulates microglia activity to suppress neuroinflammation following intracerebral hemorrhage.
The inhibitory coreceptor CD22 restores B cell signaling by developmentally regulating Cd45(-/-) immunodeficient B cells.
Title: The inhibitory coreceptor CD22 restores B cell signaling by developmentally regulating Cd45(-/-) immunodeficient B cells.
CD22 Blockage Restores Age-Related Impairments of Microglia Surveillance Capacity.
Title: CD22 Blockage Restores Age-Related Impairments of Microglia Surveillance Capacity.
CD22 Controls Germinal Center B Cell Receptor Signaling, Which Influences Plasma Cell and Memory B Cell Output.
Title: CD22 Controls Germinal Center B Cell Receptor Signaling, Which Influences Plasma Cell and Memory B Cell Output.
A CD22-Shp1 phosphatase axis controls integrin beta7 display and B cell function in mucosal immunity.
Title: A CD22-Shp1 phosphatase axis controls integrin β(7) display and B cell function in mucosal immunity.
Cullin 3 Is Crucial for Pro-B Cell Proliferation, Interacts with CD22, and Controls CD22 Internalization on B Cells.
Title: Cullin 3 Is Crucial for Pro-B Cell Proliferation, Interacts with CD22, and Controls CD22 Internalization on B Cells.
Humanized CD22 transgenic mouse model for in vivo analysis of anti-CD22-based immunotherapy.
Title: Humanized CD22 transgenic mouse model for in vivo analysis of anti-CD22-based immunotherapy.
CD22 and CD72 contribute to the development of scleroderma in a murine model.
Title: CD22 and CD72 contribute to the development of scleroderma in a murine model.
N-Linked Glycosylation Regulates CD22 Organization and Function.
Title: N-Linked Glycosylation Regulates CD22 Organization and Function.

Submit: New GeneRIF Correction See all GeneRIFs (60)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (14) 1 citation
Chemically induced (ENU) (6)
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cd22 (e-PCR), detects polymorphism
- UniSTS:141275

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CD4 receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables CD4 receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables coreceptor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables sialic acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables sialic acid binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in B cell activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell surface receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of B cell receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of B cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of calcium-mediated signaling	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of immunoglobulin production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of B cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of B cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of immune response	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IPI Inferred from Physical Interaction more info	PubMed
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: B-cell receptor CD22

Names: B-lymphocyte cell adhesion molecule; BL-CAM; T-cell surface antigen Leu-14; sialic acid-binding Ig-like lectin 2; siglec-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001043317.2 → NP_001036782.1 B-cell receptor CD22 precursor

See identical proteins and their annotated locations for NP_001036782.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer protein-coding transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC165340, AK143835

Consensus CDS

CCDS21114.1

UniProtKB/Swiss-Prot

P35329, Q3UP36, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51

UniProtKB/TrEMBL

Q3TAX0

Related

ENSMUSP00000139871.2, ENSMUST00000190617.7

Conserved Domains (3) summary

smart00408
Location:366 → 424

IGc2; Immunoglobulin C-2 Type

pfam13927
Location:260 → 334

Ig_3; Immunoglobulin domain

cl11960
Location:153 → 239

Ig; Immunoglobulin domain
NM_009845.3 → NP_033975.3 B-cell receptor CD22 precursor

See identical proteins and their annotated locations for NP_033975.3

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.

Source sequence(s)

AC165340, AK143835

Consensus CDS

CCDS21114.1

UniProtKB/Swiss-Prot

P35329, Q3UP36, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51

UniProtKB/TrEMBL

Q3TAX0

Related

ENSMUSP00000019248.7, ENSMUST00000019248.13

Conserved Domains (3) summary

smart00408
Location:366 → 424

IGc2; Immunoglobulin C-2 Type

pfam13927
Location:260 → 334

Ig_3; Immunoglobulin domain

cl11960
Location:153 → 239

Ig; Immunoglobulin domain

RNA

NR_102722.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longest transcript and uses an alternate splice junction at the 5' end of an exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC165340, AK041230
NR_102723.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice junction at the 3' end of an exon compared to variant 1, that causes a frameshift. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC165340, BC046957

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

30564829..30579767 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539493.1 → XP_006539556.1 B-cell receptor CD22 isoform X2

See identical proteins and their annotated locations for XP_006539556.1

UniProtKB/Swiss-Prot

P35329, Q3UP36, Q9JHL2, Q9JJX9, Q9JJY0, Q9JJY1, Q9R056, Q9R094, Q9WU51

UniProtKB/TrEMBL

Q3TAX0

Related

ENSMUSP00000139685.2, ENSMUST00000186154.7

Conserved Domains (3) summary

smart00408
Location:366 → 424

IGc2; Immunoglobulin C-2 Type

pfam13927
Location:260 → 334

Ig_3; Immunoglobulin domain

cl11960
Location:153 → 239

Ig; Immunoglobulin domain
XM_006539490.1 → XP_006539553.1 B-cell receptor CD22 isoform X1

See identical proteins and their annotated locations for XP_006539553.1

UniProtKB/TrEMBL

Q3TAX0

Conserved Domains (3) summary

smart00408
Location:377 → 435

IGc2; Immunoglobulin C-2 Type

pfam13927
Location:271 → 345

Ig_3; Immunoglobulin domain

cl11960
Location:164 → 250

Ig; Immunoglobulin domain
XM_006539491.3 → XP_006539554.1 B-cell receptor CD22 isoform X1

See identical proteins and their annotated locations for XP_006539554.1

UniProtKB/TrEMBL

Q3TAX0

Conserved Domains (3) summary

smart00408
Location:377 → 435

IGc2; Immunoglobulin C-2 Type

pfam13927
Location:271 → 345

Ig_3; Immunoglobulin domain

cl11960
Location:164 → 250

Ig; Immunoglobulin domain
XM_006539489.4 → XP_006539552.1 B-cell receptor CD22 isoform X1

See identical proteins and their annotated locations for XP_006539552.1

UniProtKB/TrEMBL

Q3TAX0

Conserved Domains (3) summary

smart00408
Location:377 → 435

IGc2; Immunoglobulin C-2 Type

pfam13927
Location:271 → 345

Ig_3; Immunoglobulin domain

cl11960
Location:164 → 250

Ig; Immunoglobulin domain