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Cd33 CD33 molecule [ Mus musculus (house mouse) ]

Gene ID: 12489, updated on 21-Apr-2024

Summary

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Official Symbol
Cd33provided by MGI
Official Full Name
CD33 moleculeprovided by MGI
Primary source
MGI:MGI:99440
See related
Ensembl:ENSMUSG00000004609 AllianceGenome:MGI:99440
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gp67; Siglec-3
Summary
Predicted to enable protein phosphatase binding activity and sialic acid binding activity. Predicted to be involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine phosphatase activity. Predicted to be located in several cellular components, including Golgi apparatus; external side of plasma membrane; and peroxisome. Predicted to be active in plasma membrane. Is expressed in central nervous system; genitourinary system; spleen; and submandibular gland. Orthologous to human CD33 (CD33 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E18 (RPKM 4.3), mammary gland adult (RPKM 4.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 B3; 7 28.25 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (43176823..43186679, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (43527399..43537424, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 9278 Neighboring gene Siglec family like 1 Neighboring gene zinc finger protein 658 Neighboring gene STARR-positive B cell enhancer ABC_E9290 Neighboring gene zinc finger protein 719

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen. Duan S, et al. J Clin Invest, 2019 Mar 1. PMID 30645205, Free PMC Article
  2. CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice. Brinkman-Van der Linden EC, et al. Mol Cell Biol, 2003 Jun. PMID 12773563, Free PMC Article
  3. Molecular cloning of two isoforms of the murine homolog of the myeloid CD33 antigen. Tchilian EZ, et al. Blood, 1994 Jun 1. PMID 8193354
  4. CD33/TREM2 Signaling Mediates Sleep Deprivation-Induced Memory Impairment by Regulating Microglial Phagocytosis. Tan S, et al. Neuromolecular Med, 2023 Jun. PMID 36639554
  5. TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease. Griciuc A, et al. Neuron, 2019 Sep 4. PMID 31301936, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CD33/TREM2 Signaling Mediates Sleep Deprivation-Induced Memory Impairment by Regulating Microglial Phagocytosis.
    Title: CD33/TREM2 Signaling Mediates Sleep Deprivation-Induced Memory Impairment by Regulating Microglial Phagocytosis.
  2. Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation.
    Title: Gene therapy for Alzheimer's disease targeting CD33 reduces amyloid beta accumulation and neuroinflammation.
  3. knockout of CD33 attenuated amyloid beta (Abeta) pathologyand improved cognition in 5xFAD mice, both of which were abrogated by additional TREM2 knockout. Differential gene expression in 5xFAD;CD33(-/-) microglia depended on the presence of TREM2, suggesting TREM2 acts downstream of CD33. Crosstalk between CD33 and TREM2 includes regulation of the IL-1beta/IL-1RN axis and a gene set in the "receptor activity chemokine"...
    Title: TREM2 Acts Downstream of CD33 in Modulating Microglial Pathology in Alzheimer's Disease.
  4. CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen.
    Title: CD33 recruitment inhibits IgE-mediated anaphylaxis and desensitizes mast cells to allergen.
  5. Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.
    Title: Lectin galactoside-binding soluble 3 binding protein (LGALS3BP) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.
  6. CD33-related Siglec-E recognizes the intact neuron and has neuroprotective function by preventing phagocytosis.
    Title: Microglial CD33-related Siglec-E inhibits neurotoxicity by preventing the phagocytosis-associated oxidative burst.
  7. mCD33 is expressed on myeloid precursors in the bone marrow
    Title: CD33/Siglec-3 binding specificity, expression pattern, and consequences of gene deletion in mice.
  8. SOCS3 inhibited the CD33-induced block on cytokine-induced proliferation. SOCS3 and its target protein CD33 are degraded concomitantly concomitantly.
    Title: CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover.
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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sialic acid binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myeloid cell surface antigen CD33
Names
CD33 antigen
sialic acid-binding Ig-like lectin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111058.1 → NP_001104528.1  myeloid cell surface antigen CD33 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001104528.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC154108
    Consensus CDS
    CCDS52224.1
    UniProtKB/Swiss-Prot
    A2RT59, Q63994, Q63997
    Related
    ENSMUSP00000004728.6, ENSMUST00000004728.12
    Conserved Domains (2) summary
    cd00096
    Location:21 → 25
    Ig; Ig strand A [structural motif]
    cl11960
    Location:21 → 139
    Ig; Immunoglobulin domain

  2. NM_021293.3 → NP_067268.1  myeloid cell surface antigen CD33 isoform 2 precursor

    See identical proteins and their annotated locations for NP_067268.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region that results in a frameshift compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK155745, BC132379
    Consensus CDS
    CCDS21173.1
    UniProtKB/Swiss-Prot
    Q63994
    Related
    ENSMUSP00000146225.2, ENSMUST00000205503.2
    Conserved Domains (2) summary
    smart00410
    Location:26 → 119
    IG_like; Immunoglobulin like
    cl11960
    Location:21 → 139
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    43176823..43186679 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540590.4 → XP_006540653.1  myeloid cell surface antigen CD33 isoform X1

    See identical proteins and their annotated locations for XP_006540653.1

    Conserved Domains (1) summary
    cl11960
    Location:46 → 164
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63994.1 GenPept UniProtKB/Swiss-Prot:Q63994

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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