Cdh2 cadherin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdh2provided by MGI
Official Full Name: cadherin 2provided by MGI
Primary source: MGI:MGI:88355
See related: Ensembl:ENSMUSG00000024304 AllianceGenome:MGI:88355
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CDHN; Ncad; N-CAD
Summary: This gene encodes a member of the cadherin family of calcium-dependent glycoproteins that mediate cell adhesion. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Mice lacking the encoded protein exhibit severe developmental defects resulting in embryonic death. [provided by RefSeq, Oct 2015]
Expression: Biased expression in whole brain E14.5 (RPKM 20.7), CNS E14 (RPKM 19.4) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 A1; 18 10.1 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (16721934..16942303, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (16588877..16809246, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

YAP1 controls the N-cadherin-mediated tumor-stroma interaction in melanoma progression.
Title: YAP1 controls the N-cadherin-mediated tumor-stroma interaction in melanoma progression.
N-cadherin cleavage: A critical function that induces diabetic retinopathy fibrosis via regulation of beta-catenin translocation.
Title: N-cadherin cleavage: A critical function that induces diabetic retinopathy fibrosis via regulation of β-catenin translocation.
Functional interaction between Vangl2 and N-cadherin regulates planar cell polarization of the developing neural tube and cochlear sensory epithelium.
Title: Functional interaction between Vangl2 and N-cadherin regulates planar cell polarization of the developing neural tube and cochlear sensory epithelium.
Exosomal miR-543 derived from umbilical cord mesenchymal stem cells ameliorates endometrial fibrosis in intrauterine adhesion via downregulating N-cadherin.
Title: Exosomal miR-543 derived from umbilical cord mesenchymal stem cells ameliorates endometrial fibrosis in intrauterine adhesion via downregulating N-cadherin.
ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood-testis barrier integrity.
Title: ALKBH5 in mouse testicular Sertoli cells regulates Cdh2 mRNA translation to maintain blood-testis barrier integrity.
MicroRNA-200c/429 mediated regulation of Zeb1 augments N-Cadherin in mouse cardiac mesenchymal cells.
Title: MicroRNA-200c/429 mediated regulation of Zeb1 augments N-Cadherin in mouse cardiac mesenchymal cells.
Epithelial and Neural Cadherin in Mammalian Fertilization: Studies in the Mouse Model.
Title: Epithelial and Neural Cadherin in Mammalian Fertilization: Studies in the Mouse Model.
Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells.
Title: Slc44a2 deletion alters tetraspanin and N-cadherin expression: Reduced adhesion and enhanced proliferation in cultured mesenchymal lung cells.
N-cadherin localization in taste buds of mouse circumvallate papillae.
Title: N-cadherin localization in taste buds of mouse circumvallate papillae.
CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice.
Title: CDH2 mutation affecting N-cadherin function causes attention-deficit hyperactivity disorder in humans and mice.

Submit: New GeneRIF Correction See all GeneRIFs (147)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1) 1 citation
Targeted (6) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cdh2 (e-PCR), detects polymorphism
- UniSTS:498463

RH130775 (e-PCR)
- UniSTS:214059

REN15987 (e-PCR)
- UniSTS:340787

REN16026 (e-PCR)
- UniSTS:340826

REN16027 (e-PCR)
- UniSTS:340827

Cdh2 (e-PCR), detects polymorphism
- UniSTS:265059

D18Wox24 (e-PCR)
- UniSTS:518514

Cdh2 (e-PCR), detects polymorphism
- UniSTS:545909

Cdh2 (e-PCR), detects polymorphism
- UniSTS:525985

UniSTS:498368 (e-PCR)
- UniSTS:498368

Cdh2 (e-PCR), detects polymorphism
- UniSTS:498368

D18Mit191 (e-PCR), detects polymorphism
- UniSTS:128210

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables alpha-catenin binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitric-oxide synthase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cell morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion mediated by cadherin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion mediated by cadherin	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell junction assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cerebral cortex development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in glial cell differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within homeostasis of number of cells	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mesenchymal cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neural crest cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuroepithelial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuroligin clustering involved in postsynaptic membrane assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuronal stem cell population maintenance	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of synaptic vesicle clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within radial glial cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of myelination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of oligodendrocyte progenitor proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of postsynaptic density protein 95 clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse assembly	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle clustering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within telencephalon development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in type B pancreatic cell development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	ISO Inferred from Sequence Orthology more info
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in apical part of cell	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	ISO Inferred from Sequence Orthology more info
located_in cell junction	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
colocalizes_with cortical actin cytoskeleton	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in desmosome	IDA Inferred from Direct Assay more info	PubMed
located_in fascia adherens	IDA Inferred from Direct Assay more info	PubMed
located_in fascia adherens	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in intercalated disc	IBA Inferred from Biological aspect of Ancestor more info
located_in intercalated disc	IDA Inferred from Direct Assay more info	PubMed
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
is_active_in lamellipodium	IBA Inferred from Biological aspect of Ancestor more info
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane raft	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic specialization membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in postsynaptic specialization membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic active zone membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcolemma	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cadherin-2

Names: N-cadherin; neural cadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007664.5 → NP_031690.3 cadherin-2 preproprotein

See identical proteins and their annotated locations for NP_031690.3

Status: REVIEWED

Source sequence(s)

AA242226, AC134570, AK032826, AK146981, CB246984

Consensus CDS

CCDS29076.1

UniProtKB/Swiss-Prot

P15116, Q64260, Q6GU11

UniProtKB/TrEMBL

Q8BSI9

Related

ENSMUSP00000025166.8, ENSMUST00000025166.14

Conserved Domains (4) summary

cd11304
Location:273 → 378

Cadherin_repeat; Cadherin tandem repeat domain

pfam01049
Location:759 → 902

Cadherin_C; Cadherin cytoplasmic region

pfam08758
Location:31 → 121

Cadherin_pro; Cadherin prodomain like

cl09101
Location:163 → 263

E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

16721934..16942303 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006525553.2 → XP_006525616.1 cadherin-2 isoform X1

UniProtKB/TrEMBL

D3YYT0

Conserved Domains (6) summary

cd11304
Location:236 → 341

Cadherin_repeat; Cadherin tandem repeat domain

pfam00028
Location:352 → 452

Cadherin; Cadherin domain

cl29226
Location:573 → 664

Cadherin; Cadherin domain

pfam01049
Location:714 → 867

Cadherin_C; Cadherin cytoplasmic region

cl07391
Location:19 → 84

Cadherin_pro; Cadherin prodomain like

cl28889
Location:126 → 226

CA_like; Cadherin repeat-like domain