Cdk2 cyclin dependent kinase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cdk2provided by MGI
Official Full Name: cyclin dependent kinase 2provided by MGI
Primary source: MGI:MGI:104772
See related: Ensembl:ENSMUSG00000025358 AllianceGenome:MGI:104772
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A630093N05Rik
Summary: Enables cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and magnesium ion binding activity. Involved in peptidyl-serine phosphorylation and positive regulation of cell population proliferation. Acts upstream of or within several processes, including G1/S transition of mitotic cell cycle; potassium ion transport; and regulation of cellular macromolecule biosynthetic process. Located in chromosome and nucleus. Part of cyclin-dependent protein kinase holoenzyme complex and transcription regulator complex. Is expressed in several structures, including brain; branchial arch; ear; integumental system; and limb. Human ortholog(s) of this gene implicated in prostate cancer and renal cell carcinoma. Orthologous to human CDK2 (cyclin dependent kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in limb E14.5 (RPKM 35.9), thymus adult (RPKM 24.5) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 77.13 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128533807..128540920, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128697938..128705051, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy.
Title: Lactylation-driven FTO targets CDK2 to aggravate microvascular anomalies in diabetic retinopathy.
Identification PMS1 and PMS2 as potential meiotic substrates of CDK2 activity.
Title: Identification PMS1 and PMS2 as potential meiotic substrates of CDK2 activity.
Transient inhibition of CDK2 activity prevents oocyte meiosis I completion and egg activation in mouse.
Title: Transient inhibition of CDK2 activity prevents oocyte meiosis I completion and egg activation in mouse.
Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2.
Title: Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2.
Cdk2 suppresses IL-23 expression and the onset of severe acute pancreatitis.
Title: Cdk2 suppresses IL-23 expression and the onset of severe acute pancreatitis.
CDK2 Inhibition Enhances Antitumor Immunity by Increasing IFN Response to Endogenous Retroviruses.
Title: CDK2 Inhibition Enhances Antitumor Immunity by Increasing IFN Response to Endogenous Retroviruses.
Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity.
Title: Regulation of p27 and Cdk2 Expression in Different Adipose Tissue Depots in Aging and Obesity.
Costunolide Plays an Anti-Neuroinflammation Role in Lipopolysaccharide-Induced BV2 Microglial Activation by Targeting Cyclin-Dependent Kinase 2.
Title: Costunolide Plays an Anti-Neuroinflammation Role in Lipopolysaccharide-Induced BV2 Microglial Activation by Targeting Cyclin-Dependent Kinase 2.
VEGF/CDK2 are involved in diabetic organ regeneration.
Title: VEGF/CDK2 are involved in diabetic organ regeneration.
A novel function for CDK2 activity at meiotic crossover sites.
Title: A novel function for CDK2 activity at meiotic crossover sites.

Submit: New GeneRIF Correction See all GeneRIFs (107)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (9) 1 citation
Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cdk2 (e-PCR), detects polymorphism
- UniSTS:527278

NoName (e-PCR)
- UniSTS:236489

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cyclin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin binding	IDA Inferred from Direct Assay more info	PubMed
enables cyclin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cyclin binding	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein kinase activity	ISO Inferred from Sequence Orthology more info
enables cyclin-dependent protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables cyclin-dependent protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone kinase activity	ISO Inferred from Sequence Orthology more info
enables kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in centriole replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within meiotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of DNA-templated DNA replication initiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of heterochromatin formation	ISO Inferred from Sequence Orthology more info
involved_in post-translational protein modification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion transport	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of G2/M transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in response to electrical stimulus	ISO Inferred from Sequence Orthology more info
involved_in response to organic substance	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in Cajal body	ISO Inferred from Sequence Orthology more info
located_in X chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in Y chromosome	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in condensed chromosome	IDA Inferred from Direct Assay more info	PubMed
part_of cyclin A1-CDK2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of cyclin A2-CDK2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of cyclin A2-CDK2 complex	ISO Inferred from Sequence Orthology more info
part_of cyclin E1-CDK2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of cyclin E2-CDK2 complex	IDA Inferred from Direct Assay more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cyclin-dependent protein kinase holoenzyme complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cyclin-dependent kinase 2

Names: cell division protein kinase 2

NP_058036.1

EC 2.7.11.22

NP_904326.1

EC 2.7.11.22

XP_006513225.1

EC 2.7.11.22

XP_011241623.1

EC 2.7.11.22

XP_030100713.1

EC 2.7.11.22

XP_030100714.1

EC 2.7.11.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001428414.1 → NP_001415343.1 cyclin-dependent kinase 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC117232
NM_001428415.1 → NP_001415344.1 cyclin-dependent kinase 2 isoform 3

Status: VALIDATED

Source sequence(s)

AC117232
NM_001428416.1 → NP_001415345.1 cyclin-dependent kinase 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC117232
NM_001428417.1 → NP_001415346.1 cyclin-dependent kinase 2 isoform 4

Status: VALIDATED

Source sequence(s)

AC117232
NM_016756.5 → NP_058036.1 cyclin-dependent kinase 2 isoform 2

See identical proteins and their annotated locations for NP_058036.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame coding exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC117232

Consensus CDS

CCDS24288.1

UniProtKB/TrEMBL

Q3U307, Q3U6X7

Related

ENSMUSP00000026415.8, ENSMUST00000026415.9

Conserved Domains (1) summary

cd07860
Location:3 → 286

STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3
NM_183417.4 → NP_904326.1 cyclin-dependent kinase 2 isoform 1

See identical proteins and their annotated locations for NP_904326.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC117232

Consensus CDS

CCDS24289.1

UniProtKB/Swiss-Prot

O55105, P97377

UniProtKB/TrEMBL

Q3U307, Q3UGB9

Related

ENSMUSP00000026416.8, ENSMUST00000026416.15

Conserved Domains (1) summary

cd07860
Location:3 → 334

STKc_CDK2_3; Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3

RNA

NR_190343.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC117232
NR_190344.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC117232

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

128533807..128540920 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011243321.4 → XP_011241623.1 cyclin-dependent kinase 2 isoform X1

Conserved Domains (1) summary

cl21453
Location:1 → 244

PKc_like; Protein Kinases, catalytic domain
XM_030244853.2 → XP_030100713.1 cyclin-dependent kinase 2 isoform X2

Conserved Domains (1) summary

cl21453
Location:1 → 196

PKc_like; Protein Kinases, catalytic domain
XM_030244854.1 → XP_030100714.1 cyclin-dependent kinase 2 isoform X2

Conserved Domains (1) summary

cl21453
Location:1 → 196

PKc_like; Protein Kinases, catalytic domain
XM_006513162.3 → XP_006513225.1 cyclin-dependent kinase 2 isoform X1

Conserved Domains (1) summary

cl21453
Location:1 → 244

PKc_like; Protein Kinases, catalytic domain