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Cdkn1c cyclin-dependent kinase inhibitor 1C (P57) [ Mus musculus (house mouse) ]

Gene ID: 12577, updated on 24-Aug-2021

Summary

Official Symbol
Cdkn1cprovided by MGI
Official Full Name
cyclin-dependent kinase inhibitor 1C (P57)provided by MGI
Primary source
MGI:MGI:104564
See related
Ensembl:ENSMUSG00000037664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ki; CDK; CDKI; Kip2; p57K; p57Kip2; AL024410; p57(kip2)
Expression
Biased expression in limb E14.5 (RPKM 280.3), adrenal adult (RPKM 244.3) and 10 other tissues See more
Orthologs
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Genomic context

See Cdkn1c in Genome Data Viewer
Location:
7 F5; 7 88.22 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (143012076..143014802, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (143458339..143461059, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (150644244..150646955, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel, subfamily Q, member 1 Neighboring gene KCNQ1 overlapping transcript 1 Neighboring gene RIKEN cDNA 4933417O13 gene Neighboring gene predicted gene, 33663 Neighboring gene solute carrier family 22 (organic cation transporter), member 18

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within adrenal gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within digestive system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic placenta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within genetic imprinting IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myeloid cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cyclin-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within placenta development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within placenta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of exit from mitosis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of lens fiber cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within uterus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclin-dependent kinase inhibitor 1C
Names
cyclin-dependent kinase inhibitor p57

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161624.1NP_001155096.1  cyclin-dependent kinase inhibitor 1C isoform 1

    See identical proteins and their annotated locations for NP_001155096.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AA986859, CJ175313, U20553, U22399
    Consensus CDS
    CCDS52463.1
    UniProtKB/Swiss-Prot
    P49919
    Related
    ENSMUSP00000128828.2, ENSMUST00000167912.9
    Conserved Domains (2) summary
    PTZ00341
    Location:197281
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:3481
    CDI; Cyclin-dependent kinase inhibitor
  2. NM_001354981.1NP_001341910.1  cyclin-dependent kinase inhibitor 1C isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC023248
    Consensus CDS
    CCDS22040.1
    Conserved Domains (2) summary
    PTZ00341
    Location:184268
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:2168
    CDI; Cyclin-dependent kinase inhibitor
  3. NM_009876.4NP_034006.3  cyclin-dependent kinase inhibitor 1C isoform 2

    See identical proteins and their annotated locations for NP_034006.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame splice site in the 5' coding region and uses a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA986859, CJ175313, U22399
    Consensus CDS
    CCDS22040.1
    UniProtKB/Swiss-Prot
    P49919
    UniProtKB/TrEMBL
    Q791X1
    Related
    ENSMUSP00000037302.7, ENSMUST00000037287.8
    Conserved Domains (2) summary
    PTZ00341
    Location:184268
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:2168
    CDI; Cyclin-dependent kinase inhibitor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    143012076..143014802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242048.2XP_030097908.1  cyclin-dependent kinase inhibitor 1C isoform X4

    Conserved Domains (2) summary
    PTZ00341
    Location:184268
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:2168
    CDI; Cyclin-dependent kinase inhibitor
  2. XM_030242046.2XP_030097906.1  cyclin-dependent kinase inhibitor 1C isoform X3

    Conserved Domains (2) summary
    PTZ00341
    Location:184268
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:2168
    CDI; Cyclin-dependent kinase inhibitor
  3. XM_006508470.5XP_006508533.1  cyclin-dependent kinase inhibitor 1C isoform X3

    See identical proteins and their annotated locations for XP_006508533.1

    Conserved Domains (2) summary
    PTZ00341
    Location:184268
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:2168
    CDI; Cyclin-dependent kinase inhibitor
  4. XM_030242047.2XP_030097907.1  cyclin-dependent kinase inhibitor 1C isoform X4

    Conserved Domains (2) summary
    PTZ00341
    Location:184268
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:2168
    CDI; Cyclin-dependent kinase inhibitor
  5. XM_030242045.2XP_030097905.1  cyclin-dependent kinase inhibitor 1C isoform X3

    Conserved Domains (2) summary
    PTZ00341
    Location:184268
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:2168
    CDI; Cyclin-dependent kinase inhibitor
  6. XM_006508469.5XP_006508532.1  cyclin-dependent kinase inhibitor 1C isoform X3

    See identical proteins and their annotated locations for XP_006508532.1

    Conserved Domains (2) summary
    PTZ00341
    Location:184268
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:2168
    CDI; Cyclin-dependent kinase inhibitor
  7. XM_030242044.2XP_030097904.1  cyclin-dependent kinase inhibitor 1C isoform X2

    Conserved Domains (2) summary
    PTZ00341
    Location:197281
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:3481
    CDI; Cyclin-dependent kinase inhibitor
  8. XM_006508468.5XP_006508531.1  cyclin-dependent kinase inhibitor 1C isoform X1

    See identical proteins and their annotated locations for XP_006508531.1

    Conserved Domains (2) summary
    PTZ00341
    Location:197281
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:3481
    CDI; Cyclin-dependent kinase inhibitor
  9. XM_006508467.5XP_006508530.1  cyclin-dependent kinase inhibitor 1C isoform X1

    See identical proteins and their annotated locations for XP_006508530.1

    Conserved Domains (2) summary
    PTZ00341
    Location:197281
    PTZ00341; Ring-infected erythrocyte surface antigen; Provisional
    pfam02234
    Location:3481
    CDI; Cyclin-dependent kinase inhibitor
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