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OR1M1 olfactory receptor family 1 subfamily M member 1 [ Homo sapiens (human) ]

Gene ID: 125963, updated on 5-Mar-2024

Summary

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Official Symbol
OR1M1provided by HGNC
Official Full Name
olfactory receptor family 1 subfamily M member 1provided by HGNC
Primary source
HGNC:HGNC:8220
See related
Ensembl:ENSG00000170929 AllianceGenome:HGNC:8220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR19-5; OR19-6
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
all
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Genomic context

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See OR1M1 in Genome Data Viewer
Location:
19p13.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (9087061..9095669)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (9213236..9221832)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9197737..9206345)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene mucin 16, cell surface associated Neighboring gene MED14-independent group 3 enhancer GRCh37_chr19:9150106-9151305 Neighboring gene tRNA-Gln (anticodon TTG) 8-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:9160639-9161138 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:9165241-9165920 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:9180050-9180984 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:9180985-9181918 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:9184777-9185664 Neighboring gene olfactory receptor family 1 subfamily M member 4 pseudogene Neighboring gene olfactory receptor family 7 subfamily G member 2 Neighboring gene olfactory receptor family 7 subfamily G member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
  2. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactory receptor 1M1
Names
olfactory receptor 19-6
olfactory receptor OR19-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004456.2 → NP_001004456.1  olfactory receptor 1M1

    See identical proteins and their annotated locations for NP_001004456.1

    Status: VALIDATED

    Source sequence(s)
    AC011464
    Consensus CDS
    CCDS32896.1
    UniProtKB/Swiss-Prot
    B9EHA6, Q6IFJ3, Q8NGA1, Q96R91
    UniProtKB/TrEMBL
    A0A126GVI5
    Related
    ENSP00000493107.1, ENST00000641627.1
    Conserved Domains (1) summary
    cd15918
    Location:25 → 294
    7tmA_OR1_7-like; olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    9087061..9095669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    9213236..9221832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NGA1.1 GenPept UniProtKB/Swiss-Prot:Q8NGA1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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