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Chil3 chitinase-like 3 [ Mus musculus (house mouse) ]

Gene ID: 12655, updated on 5-Jan-2022

Summary

Official Symbol
Chil3provided by MGI
Official Full Name
chitinase-like 3provided by MGI
Primary source
MGI:MGI:1330860
See related
Ensembl:ENSMUSG00000040809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ym1; ECF-L; Chi3l3; AI505981
Summary
The protein encoded by this gene is similar to bacterial chitinases but lacks chitinase activity. The encoded protein is thought to function as a lectin and may be involved in inflammation and allergy. [provided by RefSeq, Sep 2015]
Expression
Biased expression in lung adult (RPKM 97.4) and liver E18 (RPKM 36.9) See more
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Genomic context

See Chil3 in Genome Data Viewer
Location:
3 F2.2; 3 46.49 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (106054870..106074880, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (106147554..106167564, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (105950472..105970482, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene Neighboring gene chitinase, acidic 1 Neighboring gene chitinase-like 4 Neighboring gene chitinase 3-like 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetyl-beta-D-galactosaminidase activity IEA
Inferred from Electronic Annotation
more info
 
enables beta-N-acetylhexosaminidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carbohydrate binding TAS
Traceable Author Statement
more info
PubMed 
enables chitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables chitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
chitinase-like protein 3
Names
beta-N-acetylhexosaminidase Ym1
eosinophil chemotactic cytokine
eosinophil chemotactic factor-L
secreted protein Ym1
NP_034022.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009892.3NP_034022.2  chitinase-like protein 3 precursor

    See identical proteins and their annotated locations for NP_034022.2

    Status: REVIEWED

    Source sequence(s)
    AC125461, AK137503
    Consensus CDS
    CCDS17718.1
    UniProtKB/Swiss-Prot
    O35744
    Related
    ENSMUSP00000053923.9, ENSMUST00000063062.9
    Conserved Domains (2) summary
    cd02872
    Location:24387
    GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...
    smart00636
    Location:26365
    Glyco_18; Glyco_18 domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    106054870..106074880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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